Results 231 to 240 of about 2,387,410 (293)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

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Selecting Startups as Suppliers: A Typology of Supplier Selection Archetypes

Journal of Supply Chain Management, 2020
Recent research highlights opportunities to study collaborations between established firms and startups from a buyer–supplier relationship perspective. However, before firms can leverage startups’ resources and capabilities in a buyer–supplier relationship, they need to identify, evaluate, and select suitable startups as their suppliers.
Stefan Kurpjuweit, Stephan M. Wagner, Thomas Y. Choi   +2 more
openaire   +1 more source

Supplier Selection Model Research

Proceedings of the 2020 11th International Conference on E-Education, E-Business, E-Management, and E-Learning, 2020
In the process of Purchasing, selectingsuppliers is an important mean and precondition for obtaining high-quality products. In this paper, we analyze some factors affecting supplier selection, such as product quantity, production price, product quality and product delivery time, formulate a supplier selection model based on linear weighted multi ...
Xiaosong Li, Xinran Peng, Tian Liu, Mingxing Yuan   +3 more
openaire   +1 more source

A Model for B2B Supplier Selection

2011
A supply chain is a set of geographically dispersed facilities that store and transform products, and that are connected by a transportation network. The main task of supply chain management is to design the supply chain so that a given set of objectives is achieved, for example by deciding the location and capacity of new production plants, or the ...
Gianluca Campanella, Rita A. Ribeiro, Leonilde R. Varela   +2 more
openaire   +2 more sources

Supplier selection model with contingency planning for supplier failures

Computers & Industrial Engineering, 2013
We consider the optimal allocation of demand across a set of suppliers given the risk of supplier failures. We assume items sourced are used in multiple facilities and can be purchased from multiple suppliers with different cost and reliability characteristics.
Alex J. Ruiz-Torres, Farzad Mahmoodi, Amy Z. Zeng   +2 more
openaire   +2 more sources

Global supplier selection strategies and implications for supplier performance: Turkish suppliers’ perception

International Journal of Logistics Research and Applications, 2009
In today's global competitive environment, supplier evaluation and selection strategies are not only important for buyer performance and competitiveness, but also for supplier performance and capabilities. This study from the suppliers’ perception examines (i) the structure of supply relationships between Turkish automotive parts and components ...
TUNA, OKAN, Inemek, A.
openaire   +2 more sources