Results 131 to 140 of about 3,148,526 (314)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

AI in supply chain: Techniques, applications, real-world cases and benefits under SCOR framework [PDF]

This article focuses on practical perspectives of Artificial Intelligence (AI) applications in Supply Chain Management by exploring commonly used AI techniques, use cases and benefits of applying AI in Supply Chain Management with real-world examples ...
Briš, Petr, Pham Hoang, Bao
core  

The strategic fit of supply chain integration in the TFT-LCD industry [PDF]

, 2010
[[abstract]]Purpose - The purpose of this paper is to identify what kind of supply chain integration strategies can support TFT-LCD manufacturers seeking to break through the cost constraints and complex co-operation relationships between manufacturers ...
沙永傑; D.Y.Sha; P.K.Chen; 陳永信; Chen, Yung-Hsin
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Mapping the supply of nature’s contributions to people on Mount Kilimanjaro

Environmental Research Letters
Mount Kilimanjaro, with its steep elevational gradient (770–5886 m a.s.l.) and pronounced land-use heterogeneity, supports high biodiversity and diverse nature’s contributions to people (NCP), but it is underrepresented in global spatial assessments.
Netra Bhandari, Neema Robert Kinabo, Dominic Andreas Martin, Andrea Larissa Boesing, Margot Neyret, Gaëlle Bocksberger, Jörg Albrecht, Tim Appelhans, Ugo Arbieu, Joscha N Becker, Giovanni Bianco, Robert Modest Byamungu, Alice Classen, M Eugenia Degano, Friederike Gebert, Milena Gross, Claudia Hemp, Victoria Junquera, Ralf Kiese, Koggani D Koggani, Armin Komposch, Yakov Kuzyakov, Dickson Gerald Mauki, Antonia V Mayr, Thomas Müller, Henry K Njovu, Insa Otte, Jasmine Pearson, Marcell K Peters, John Sanya, Matthias Schleuning, Ingolf Steffan-Dewenter, Maximilian G R Vollstaedt, Jie Zhang, Katrin Böhning-Gaese, Markus Fischer, Andreas Hemp, Peter Manning, Dirk Zeuss   +38 more
doaj   +1 more source

Applications of Machine Learning in the Supply Chain

, 2018
Presented on February 15, 2018 at 12:00 p.m. in the Georgia Tech Manufacturing Institute, 1st floor auditorium.Sebastian Pokutta is the David M. McKenney Family Associate Professor in the Stewart School of Industrial & Systems Engineering at Georgia Tech.
Pokutta, Sebastian
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source