Results 251 to 260 of about 6,656,292 (362)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Potential impacts of landuse changes on the supply-demand relationship of water resources in semiarid loess hilly regions. [PDF]

Sci Rep
Qiao L, Li Q, Zhang H, Zhang Z, Yang H, Zhu Y, Mao Z.   +6 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Using Risk-Benefit Analysis and the Analytical Hierarchy Process to Decide on the Implementation of Rapid Salmonella Detection Methods in Large Poultry Industries. [PDF]

Risk Anal
Magalhães CRP, de Aquino NSM, Tondo EC.
europepmc   +1 more source

Review of: "Enhancing Supply Chain Management Risk Mitigation: A House of Risk Methodology Applied to Brick Manufacturing in Aceh Besar Regency" [PDF]

Umair Manzoor
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

From crisis to recovery: Exploring the demand surge for mental health services in Alberta, Canada-A document-based policy analysis with an illustrative supply-demand simulation (2023-2024). [PDF]

PLOS Ment Health
Adegoke K, Adegoke A, Dawodu D, Bayowa A, Adekoya A, Kayode T, Singh M, Durojaye OA, Aluko AI, Adegoke A.   +9 more
europepmc   +1 more source

Effect measurement of Sustainable Supply Chain Governance - Systems: The development and test of a valid, reliable and manageable measurement system

, 2010
RJ Wieringa
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Enhanced supply selection for better initial basic feasible solutions in transportation problems. [PDF]

MethodsX
Bunyamin RF, Amaliah B, Saikhu A.
europepmc   +1 more source