Results 121 to 130 of about 518,164 (317)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Transportation: A Global Supply Chain Perspective [PDF]

, 2019
Equip students with an understanding of what may be the most critical and complex component of global supply chains with TRANSPORTATION: A SUPPLY CHAIN PERSPECTIVE, 9E.
Gibson, Brian, Suzuki, Yoshinori, Novack, Robert, Coyle, John   +3 more
core  

Double Deep Q-Network-Based Solution to a Dynamic, Energy-Efficient Hybrid Flow Shop Scheduling System with the Transport Process

Systems
In this paper, a dynamic energy-efficient hybrid flow shop (TDEHFSP) scheduling model is proposed, considering random arrivals of new jobs and transport by transfer vehicles.
Qinglei Zhang, Huaqiang Si, Jiyun Qin, Jianguo Duan, Ying Zhou, Huaixia Shi, Liang Nie   +6 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Developing supply chain maturity [PDF]

This study introduces an empirical model of supply chain maturity and assesses its impact upon performance. Findings suggest that supply chain maturity is multi-dimensional including the areas of planning, sourcing, making, delivering, new product ...
Done, Adrian
core  

Performance in humanitarian supply chains [PDF]

, 2014
The goals of humanitarian organizations are to save lives, decrease human suffering, and contribute to development. However, humanitarian response has been criticized for its lack of positive impact on the societies receiving aid, or more precisely, for ...
Haavisto, Ira
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Green House Gas Emission Analysis in the Food Processing Industry: A Case Study of MSME in South India

Engineering Proceedings
Rising carbon emissions are worsening global climatic conditions, posing a grave threat to the environment. Analysing and reducing carbon footprints are vital for combating climate change.
Gangavarapu Chenchu Chythanya Krishna, Chelakari Ravi Karthika, Chindukuru Sushwanth, Guggila Hema Gopi Chand, Firoz Nasirudeen, Vinay V. Panicker   +5 more
doaj   +1 more source