Results 201 to 210 of about 372,477 (307)

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

Ferritin‐Doped Nanoparticles Triggered Tumor‐Specific Darkening for Enhanced Photothermal Tumor Ablation and Immune Activation

Advanced Healthcare Materials, EarlyView.
Ferritin‐doped hybrid nanoparticles triggered accurate tumor‐specific hemorrhage for enhanced in situ photothermal therapy and evoked anti‐tumor immunity. Notably, HFn/GA‐Fe specifically induced tumor hemorrhage 12 h after intravenous injection, resulting in visible color darkening. Through photoacoustic imaging, tumor vessels could be clearly observed
Haidong Zha, Xiao Liang, Long Xi, Jiamao Chen, Wenzhao Zhong, Zhen Yuan, Meng Xu, Ying Zheng   +7 more
wiley   +1 more source

Sci-Tech finance efficiency promotes the construction of a modernized industrial system evidence from double machine learning. [PDF]

Sci Rep
Huang R, Liu X, Tian J, Liu C, Wang S, Zhang Q.   +5 more
europepmc   +1 more source

3D‐Printed Titanium Implants with Bioactive Peptide‐Polysaccharide Scaffolds for Personalized Bone Reconstruction

Advanced Healthcare Materials, EarlyView.
Porous 3D‐printed titanium implants are made bioactive by integration with a supramolecular peptide‐hyaluronic acid nanofibrillar scaffold, without the addition of exogenous cells or growth factors. Uniform filling of the implant architecture promotes vascularized, spatially homogeneous bone regeneration, significantly enhancing osteogenesis throughout
Noam Rattner, Vladimir Perlis, Eran Golden, Ariel Pokhojaev, Rachel Sarig, Itzhak Binderman, Michal Halperin‐Sternfeld, Solomon Dadia, Lihi Adler‐Abramovich   +8 more
wiley   +1 more source

The practice of drug emergency supply in China during the COVID-19 pandemic: A policy mix perspective. [PDF]

PLoS One
Jie-Ying Z, Jun L, Xue-Ya W, Rui-Xue F, Feng Z, Yi T, Jun-Lin Z, Ning-Ying M.   +7 more
europepmc   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

The impact of blockchain adoption on supply chain financing and E-commerce platform dynamics. [PDF]

PLoS One
Pi S.
europepmc   +1 more source

Flexible Polypyrrole‐Based pH Sensors via Oxidative Chemical Vapor Deposition

Advanced Healthcare Materials, EarlyView.
Oxidative chemical vapor deposition (oCVD) of polypyrrole (PPy) thin films yields flexible, electrically conductive, and biocompatible pH sensors for monitoring on‐skin biological events. The highly sensitive, oCVD PPy skin‐conformal sensors enable real‐time, spatially resolved sensing of dynamic pH changes within physiologically relevant ranges (4–9 ...
Adrivit Mukherjee, Federico Ferrari, David Garcia Romero, Ilaria Squillante, Job Schoenmaker, Hamoon Hemmatpour, Anton Terpstra, Peter Dijkstra, Julien Es Sayed, L. Jan Anton Koster, Maria Antonietta Loi, Petra Rudolf, Giuseppe Portale, Ajay Giri Prakash Kottapalli, Marleen Kamperman, Ranjita K. Bose   +15 more
wiley   +1 more source