Results 41 to 50 of about 372,477 (307)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Overcoming SMEs Financing and Supply Chain Obstacles by Introducing Supply Chain Finance [PDF]

International Journal of Business and Management, 2018
Keeping in view the importance of small and medium enterprises (SMEs) for the growth of a nation, we must also keep an eye on the challenges faced by those SMEs. There are various kinds of financing and supply chain options available for SMEs but they still face lot of hindrances.
Waseem Ahmed Abbasi, Zongrun Wang, Asaad Alsakarneh   +2 more
openaire   +2 more sources

A Study on Risk of Supply Chain Finance——Take the Supply Chain Finance Business of Company A for Example [PDF]

, 2015
供应链金融,这种新兴的融资方式，为商业银行拓展了新的业务和市场，也为各个产业，尤其是产业链条中的中小企业拓宽了新的融资途径。但，供应链金融所蕴含的风险也更为巨大，因为它不再以单个企业作为评价基础，而是综合考察核心企业的信用评价和物流监管企业运营情况对整条供应链上的企业进行授信。因此，在供应链金融迅速发展的背景下，正确分析其存在的风险问题具有一定的现实意义。 本文主要采用定性分析和案例研究相结合的方法，以核心企业的视角展开，从道德风险、操作风险等角度分析供应链金融的风险问题。首先，对供应链金融的概念 ...
王支良
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Quantifying Credit Risk of Supply Chain Finance: A Chinese Automobile Supply Chain Perspective

IEEE Access, 2019
Credit risk is a major risk of supply chain finance business, and it has recently gained increasing attention. Due to the high dependence between enterprises, the assessment of the supply chain finance risk will be more complicated. In the current study,
Min Zhang, Jiantong Zhang, Ruolin Ma, Xiaodong Chen   +3 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Determinants of Non-Hydro Renewable Energy Consumption in China’s Provincial Regions

Energies
This study investigates the determinants of non-hydro renewable energy (NHRE) consumption across 31 provincial regions in China, spanning from 2015 to 2022. Utilizing fixed effects and moderating effects, the research analyzes the impacts of research and
Yuanbo Hu, Weilun Huang, Aibi Dai, Xuemeng Zhao   +3 more
doaj   +1 more source

The Application and Optimization Path of Supply Chain Finance in Financing for Small and Medium-Sized Enterprises [PDF]

SHS Web of Conferences
With the acceleration of economic globalization and market competitiveness, small and mediumsized businesses confront numerous problems in extending their business and capital operations.
Teng Youming
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Framing Sustainable Supply Chain Finance: how can supply chain sustainability practices and supply chain finance solutions be integrated?

Journal of Purchasing and Supply Management, 2023
Supply chain finance (SCF) can play a role in improving supply chain (SC) sustainability. That is why academics have started investigating the connection between SCF and sustainable SC management, and practitioners have begun developing new SCF solutions with a sustainable orientation.
Medina E., Caniato F., Moretto A.
openaire   +1 more source