Results 41 to 50 of about 3,642,667 (305)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Leveraging Blockchain for Transparency: A Study on Organ Supply Chains and Transplant Processes

Logistics
Background: Organ transplants require proper monitoring and tracking. This research examines the adoption of blockchain in the organ supply chain to bring transparency and help patients avoid the fraud that may be faced in the organ transplant process ...
Rashmi Ranjan Panigrahi, Subhodeep Mukherjee, Zakir Hossen Shaikh, Naji Mansour Nomran   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Evaluating the strategic role of stringent environmental policies and innovative technologies in China’s green energy transitions

Scientific Reports
China’s massive reliance on fossil energy consumption is considered as the major hindrance in achieving carbon neutrality and environmental protection goals.
Zulqarnain Mushtaq, Jiequn Guo, Cunpu Li, Han Lyu, Jie Liu   +4 more
doaj   +1 more source

Beyond adoption: Analysing the sufficient and necessary factors for ai-driven sustainable performance in an emerging economy

Sustainable Futures
The study examines the impact of drivers of artificial intelligence adoption on the sustainable performance of manufacturing firms in Ghana. Further, it determines which of the drivers are essential prerequisites for achieving sustainability.
Benedict Ofori Antwi, Daniel Agyapong, Dominic Owusu   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

An analysis on Supply Chain Performance Measurement

, 2020
In today’s business processes it has been stated, that a successful supply chain (SC) is a key factor to increase the company’s productivity and profitability and consequently leads to a competitive advantage.
Berg, Carina, Kern, Marina, Pham, Lan Jie, Schlemermeyer, Gesa   +3 more
core   +1 more source

Establishment of Passenger Car Equivalent (PCE) Values for Urban Intersections Using Drones

Future Transportation
Passenger Car Equivalent (PCE) factors are widely used to convert heterogeneous traffic streams into equivalent homogeneous flow rates for the design and analysis of roads and intersections.
Pramodh Senanayake, Loshaka Perera, Ruwantha Wimalasiri, Ranjit Godavarthy   +3 more
doaj   +1 more source

Research on financial risk management and control of agricultural products supply chain—A case study of Jiangsu Province of China

Frontiers in Environmental Science, 2022
Agriculture has always been the focus of all countries, the rapid development of agriculture is inseparable from the strong support of finance. As a new financial model, agricultural product supply chain finance has attracted much attention.
Jing Yang, Decai Tang, Decai Tang, Haojia Kong, Valentina Boamah   +4 more
doaj   +1 more source