Results 111 to 120 of about 18,853,644 (228)

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

Assessment of vaccination competency among health workers in health facilities in East Wollega, Oromia, Western Ethiopia: An observational study. [PDF]

PLoS One
Olani A, Bayisa G, Chala M, Gurmessa L, Fayera J.   +4 more
europepmc   +1 more source

Supply Chain Automation - Veterans Brochure

This brochure, provided by the National Center for Supply Chain Automation, is intended for Veterans and includes information on careers in supply chain automation.

core  

Development of an Approach for Analyzing Supply Chain Complexity [PDF]

Supply chains are faced with a rising complexity of products, structures, and processes. Because of the strong link between a supply chain’s complexity and its efficiency the supply chain complexity management becomes a major challenge of today’s ...
Meyer, Christian, Kersten, Wolfgang, Blecker, Thorsten   +2 more
core  

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

From classrooms to practice: does pre-service training for one health professions provide readiness for antimicrobial stewardship? [PDF]

BMC Med Educ
Ade-Yusuf OR, Chikezie NC, Abdussalam BO, Issaka N, Bekele BK, Mahmoud A, Tsogbetse RAA, Damilare S, Egwu KC, Ukoh CM, Ramde WZ, Duodu CY, Ogu CC, Iziomo PM, Majekodunmi AO, Mbadiwe E.   +15 more
europepmc   +1 more source

FBP1‐Mediated Compartmentalization of Glycolytic Enzyme Complexes Suppresses PKM2 Function to Ameliorate MASLD Progression

Advanced Science, EarlyView.
In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang, Yiping Tang, Na Li, Xuening Dai, Jing Wu, Bin Xue, Yuxin Chen, Jingzi Zhang, Lingdong Kong, Chaojun Li, Lei Fang   +10 more
wiley   +1 more source

Healthcare providers' perspectives on factors influencing treatment choices for HIV-associated cryptococcal meningitis in Tanzania: a qualitative exploratory study in two regional referral hospitals. [PDF]

BMJ Open
Mutagonda RF, Msongela M, Kinyonga MV, Omary MB, Musiba GN, Kilonzi M.   +5 more
europepmc   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Financial Knowledge or Managerial Competence? Disentangling Financial Literacy and Liquidity Constraints for Processing Continuity and Food Security in the Turkish Tea Industry. [PDF]

Foods
Gün M, Savcı M.
europepmc   +1 more source