Results 21 to 30 of about 18,853,644 (228)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A Methodology for Engineering Competencies Definition in the Aerospace Industry [PDF]
Journal of Systemics, Cybernetics and Informatics, 2011 The need to cut off lead times, to increase the products innovation, to respond to changing customer requirements and to integrate new technologies into business process pushes companies to increase the collaboration.
Laura Fortunato +4 more
doaj
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
A Bibliometric Research Trend Analysis of the Impact of Knowledge Sharing on Organizational Capabilities and Organizational Performance [PDF]
مدیریت راهبردی دانش سازمانیPurpose: In the era of a knowledge-based economy, knowledge sharing is recognized as a key factor shaping organizational capabilities and enhancing organizational performance. The advancement of emerging technologies, such as artificial intelligence (AI),
Mahboubeh Daneshyar, Ameneh Khadivar
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Reward and Promotion: Sustainable Value of Post Pandemic Efforts in Medical Cold-Supply Chain
Aptisi Transactions on TechnopreneurshipThis research was carried out in one of the main logistics centers called the Nusantara Bonded Zone which houses many transportation and logistics companies, especially medical cold supply chains.
Mohammad Annas +4 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
An agent-based dynamic information network for supply chain management [PDF]
, 2004 One of the main research issues in supply chain management is to improve the global efficiency of supply chains. However, the improvement efforts often fail because supply chains are complex, are subject to frequent changes, and collaboration and ...
Lee, H, Ahn, H
core +1 more source
Big Data Analytics for controlling supply chain performance
, 2021 Congestion delay produces logistical consequences for the supply chain performance for stored goods. A delayed delivery produces disruption at the next level in the supply chain. To deal with this problem, the study demonstrate the use of Google data, in
Riemer, Torben, Warnke, Phillip
core +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source