Results 21 to 30 of about 3,832 (228)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A Methodology for Engineering Competencies Definition in the Aerospace Industry [PDF]
Journal of Systemics, Cybernetics and Informatics, 2011 The need to cut off lead times, to increase the products innovation, to respond to changing customer requirements and to integrate new technologies into business process pushes companies to increase the collaboration.
Laura Fortunato +4 more
doaj
Incentive mechanism based on cooperative advertising for cost information sharing in a supply chain with competing retailers [PDF]
Journal of Industrial Engineering International, 2017 Abstract This paper proposes a new motivation for information sharing in a decentralized channel consisting of a single manufacturer and two competing retailers. The manufacturer provides a common product to the retailers at the same wholesale price. Both retailers add their own values to the product and distribute it to consumers.
Setak, Mostafa +2 more
openaire +3 more sources
Modern Supply Chain Research and Applications, 2023 PurposeThe study examined the influence of small and medium enterprise (SME) owner-managers' managerial competencies on supply chain performance, the mediation role of information quality on the SME owner-managers' managerial competencies and supply chain performance relationship, the mediating role of information quality on the information sharing and
Namagembe, Sheila, Mbago, Musa
openaire +3 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
A Bibliometric Research Trend Analysis of the Impact of Knowledge Sharing on Organizational Capabilities and Organizational Performance [PDF]
مدیریت راهبردی دانش سازمانیPurpose: In the era of a knowledge-based economy, knowledge sharing is recognized as a key factor shaping organizational capabilities and enhancing organizational performance. The advancement of emerging technologies, such as artificial intelligence (AI),
Mahboubeh Daneshyar, Ameneh Khadivar
doaj +1 more source
Uncertain Supply Chain Management, 2021 This study aims to find empirical evidence regarding the factors that affect the quality of information systems and the quality of supply chain management as seen from the environmental uncertainty of the organizational structure and the distribution network competence in manufacturing companies in Medan, Indonesia.
Widia Astuty +3 more
openaire +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Reward and Promotion: Sustainable Value of Post Pandemic Efforts in Medical Cold-Supply Chain
Aptisi Transactions on TechnopreneurshipThis research was carried out in one of the main logistics centers called the Nusantara Bonded Zone which houses many transportation and logistics companies, especially medical cold supply chains.
Mohammad Annas +4 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source