Results 91 to 100 of about 147,439 (262)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

The uncertainty–risk–efficiency pathway: Evidence from supply chains operating amid the Sudan conflict

open access: yesJournal of Transport and Supply Chain Management
Background: Environmental uncertainty, characterised by rapid changes in macroeconomic policies, geopolitical instability, and sectoral volatility, has become a major driver of supply chain risk.
Abdelsalam A. Hamid   +3 more
doaj   +1 more source

Designing Strategic Management System for Supply Chain Risk [PDF]

open access: yesمطالعات مدیریت راهبردی, 2018
Today, intense competition between manufacturers, increasing innovation and reducing the life span of products has led to the design, production and marketing of products for a variety of purposes, and the types of risks involved in large-scale design ...
Mahmood Yahyazadeh Far   +3 more
doaj  

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Mitigating supply chain risks of concentrate feed for the dairy cows through smart supply chain implementation

open access: yesJournal of Industrial Engineering and Management
Purpose: This research aims to mitigate risks within the MAKO (concentrate feed for the dairy cows) supply chain by integrating the House of Risk (HOR) method with the application of smart supply chain technologies based on the Internet of Things (IoT ...
Iphov Kumala Sriwana   +2 more
doaj   +1 more source

Essays on supply-chain risk management [PDF]

open access: yes, 2015
This dissertation aims to improve risk management in supply chains. We focus on both supply-side and demand-side risks, which have grown in importance as supply chains have become more global and complex. Traditionally, the operations management literature has treated both supply and demand uncertainty as exogenous. We relax these assumptions and delve
openaire   +1 more source

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