Results 41 to 50 of about 676,179 (295)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Highlighting the Importance of Considering the Impacts of Both External and Internal Risk Factors on Operational Parameters to Improve Supply Chain Risk Management

IEEE Access, 2019
Operational risk management in supply chain activities is important for the successful achievement of the desired outcomes. Although it is an active area of research with an aim of improving a firm's success in its operations, a drawback of existing ...
Abdullah Salamai, Omar K. Hussain, Morteza Saberi, Elizabeth Chang, Farookh Khadeer Hussain   +4 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Stochastic Supply Chain Optimization with Risk Management

Chemical Engineering Transactions, 2019
This paper presents the hypothetical case study of supply-chain management of the carbon dioxide-utilization products where its feedstock is sewage gas containing mostly methane and CO2. This supply chain begins with three suppliers sending sewage gas of
Narut Suchartsunthorn, Kitipat Siemanond
doaj   +1 more source

Analysis and prioritization of risk factors in the management of Halal supply chain management

Discover Sustainability, 2021
In the competitive globalized market, risk management is an important aspect of the supply chain, but it becomes crucial to the management of a faith-based supply chain. The halal supply chain is an emerging research era at an early stage.
Adnan Sarwar, Aqsa Zafar, Alia Qadir
doaj   +1 more source

Option contracts in fresh produce supply chain with circulation loss [PDF]

, 2013
Purpose: The purpose of this paper is to investigate management decisions via option contracts in a two-stage supply chain in which a fresh produce supplier sells to a retailer, considering the circulation loss of the fresh produce. Design/methodology/
Chen, Xu, Wang, Chong
core   +3 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Linking supply chain risk management to financial performance of SMEs: can supply chain collaboration moderate?

African Business Management Journal
While supply chain risk management is widely recognised for mitigating disruptions and enhancing operational efficiency, its impact on the financial performance of manufacturing small and medium-sized enterprises remains underexplored, particularly when
Michael Patrick Chuwa, Furaha Edwin Mlay, Ambali Kitalima   +2 more
doaj   +1 more source

Supply Chain Risk Mapping at ABC Cement Plant in Aceh, Indonesia

Aceh International Journal of Science and Technology, 2022
Supply Chain Risk Management is an industry collaboration that works with partners in the supply chain system to implement a risk management process in dealing with the emergence of risks and uncertainties caused by logistics activities or other ...
Raihan Dara Lufika*, Hasan Yudie Sastra, Prima Denny Sentia, Ilyas Ilyas, Iskandar Iskandar   +4 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source