Results 131 to 140 of about 697,411 (311)

Establishing a framework for the effective design of resilient supply chains with inherent non-linearities [PDF]

, 2015
Purpose of this paper: Previous control theory research on supply chain dynamics has predominantly taken a linear perspective of the real world, whereas nonlinearities have usually been studied via a simulation approach.
Naim, MM, Potter, AT, Spiegler, VLM, Towill, DR   +3 more
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Investigating the role of innovation over collaborative relation intensity in supply chains [PDF]

, 2010
This paper discusses investigating the role of innovation over collaborative relation intensity in supply chains.
Bititci, Umit, Mokadam, M
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Agricultural and food business dynamics in the Mediterranean region: Identifying key indicators for sustainable supply chain systems originated by small-scale farming production

New Medit
Fruit and vegetables play a crucial role in ensuring food and nutrition security, and developing more sustainable value chains in agriculture and the agri-food sector.
Paolo Prosperi, Yazdan Soltanpour, Sina Ahmadi Kaliji, Lhoucine Ouahi, Mohamed Ait Hou, Charisios Achillas, Hager Ahmed, Dimitrios Aidonis, Luca BARTOLI, Marcello DE ROSA, Ahmed Ghannouchi, Justus Harm, Evagelos D. Lioutas, Teresa Terilli, Luca CAMANZI   +14 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

SUPPLY CHAIN MANAGEMENT IN THE FRESH PRODUCE INDUSTRY: A MILE TO GO? [PDF]

We investigate the factors that influence vertical coordination in the fresh produce industry. Elaborating on the concept of governance structure, price and non-price coordination systems will be distinguished.
Zuurbier, Peter J.P.
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Geographical linkage and trade disruption within global photovoltaic supply chains

Geography and Sustainability
Photovoltaics play an essential role in supporting the unprecedented growth of renewable energy transition as well as facing a series of trade risks due to complex international dynamics and intermittent trade disruptions.
Weilong Li, Meng Zhang, Mengyao Han
doaj   +1 more source

Trade Collapse, Trade Relapse and Global Production Networks: Supply Chains in the Great Recession (revised) [PDF]

Global supply chains reshaped international trade since the 1980s. Their role in explaining the trade collapse that followed the financial crisis of September 2008 was significant.
Escaith, Hubert
core   +1 more source