Results 121 to 130 of about 11,318,306 (287)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Sustainable clinical laboratory capacity for health in Africa

The Lancet Global Health, 2017
Justine Davies, Alash'le Abimiku, Moses Alobo, Zoë Mullan, Rachel Nugent, Miriam Schneidman, Welile Sikhondze, Philip Onyebujoh   +7 more
doaj   +1 more source

Stability analysis of complex intersection point and supporting technology of concrete-filled steel tube pier column group

Meitan xuebao
Roadway intersection point are critical in underground mining and significantly impact mine safety. To address challenges such as large unsupported roof areas, concentrated stress, and difficult support in deep complex intersection point, a study is ...
Jun WANG, Zhaolong WU, Yang LIU, Yuliang WU, Bo WANG, Jie LIU, Chuangen ZHU, Shunzhang LYU   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Managing transition. Support for individuals at key point of change

International Journal of Integrated Care, 2010
AnneLoes van Staa
doaj   +3 more sources

Laser point cloud segmentation algorithm for hydraulic support based on neighborhood feature encoding and optimization

Gong-kuang zidonghua
Due to the influence of underground coal dust and easy obstruction, the laser point cloud data of hydraulic supports is prone to be incomplete. The existing point cloud segmentation algorithms are difficult to obtain fine-grained point cloud features ...
WANG Junfu, XUE Xiaojie, YANG Yi
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Optimization Design for Support Points of the Body-Mounted Solar Panel

Aerospace
Body-mounted solar panels are extensively utilized in satellite construction due to their simple structure and robust vibration resistance. The quantity and arrangement of support points on the body-mounted solar panel significantly affect its natural ...
Qingwu Liu, Jisong Yu, Zhenjia Wang, Hao Cheng, Shanbo Chen, Lei Zhang   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source