Results 91 to 100 of about 2,698,960 (264)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

An ontology-based web decision support system to find entertainment points of interest in an urban area

Geo-spatial Information Science
In recent years, decision support systems (DSSs) have successfully deployed ontologies in their architecture. The result of such a use is information systems that assist users and organizations in semi-structured decision-making activities. Visitors from
Mohammad H. Vahidnia, Mojde Minaei, Saeed Behzadi   +2 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Clinician Preferences in Provision of Respiratory Support to Patients With Respiratory Failure Receiving Intensive CareTake-Home Points

CHEST Critical Care
Background: Acute respiratory failure is a common and deadly diagnosis among patients receiving intensive care. Physicians have a variety of oxygenation support devices available to support patients, ranging from low-flow oxygen to high-flow nasal ...
Peter C. Nauka, MD, Eric J. Yablonsky, BS, S. Mehdi Nouraie, MD, Timothy D. Girard, MD, MSCI, Jeremy M. Kahn, MD, Bryan J. McVerry, MD, Christopher W. Seymour, MD   +6 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Desistência do crime

Sociedade e Estado
Resumo O texto explora o conceito da desistência criminal, cada vez mais empregado na literatura criminológica contemporânea, a discutir o tema da estabilidade e da mudança comportamental a partir de novas bases teóricas.
Marcos Rolim
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Adolescent mental health utilization, virtual care, and community support: evidence from 2019 to 2022

Frontiers in Public Health
ObjectiveThis study examined racial and ethnic disparities in mental health service use, social support, and telemedicine access among U.S. adolescents between 2019 and 2022.MethodsWe analyzed nationally representative data from 2019 to 2022 National ...
William Youkang Zhou, Luisa Franzini, Arturo Vargas Bustamante   +2 more
doaj   +1 more source