Results 201 to 210 of about 9,731,853 (303)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Impact of Healthcare Professionals' Characteristics on the Evaluation of Clinical Decision Support Systems: Insights from a Cross-Country Usability and Technology Acceptance Study of the iCARE Tool. [PDF]

J Med Syst
Nuutinen M, Hiltunen AM, Leskelä RL, Messo M, Salminen A, Lahelma M, de Almeida Mello J, Declercq A, Švihnosová O, Langmaierová K, Fialová D, Mammarella F, Liperoti R, Exmann C, van Hout H, Pešić V, Howard E, Stodolska A, Szczerbińska K, Alon M, Haavisto I.   +20 more
europepmc   +1 more source

Clinical Decision Support Systems [PDF]

, 2011
Dinevski, Dejan, Bele, Uroš, Šarenac, Tomislav, Rajkovič, Uroš, Šušteršič, Olga   +4 more
openaire   +3 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Interorganizational Mechanisms for Developing and Implementing Clinical Decision Support Systems in Primary Care: Exploratory, Qualitative Case Study.

J Med Internet Res
Santema JJMM, van Wijngaarden JDH, Hiddink EG, Deken F, Kleinsmann M, van Os HJA.   +5 more
europepmc   +1 more source

The user experiences of AI-based clinical decision support systems and implications for usage over time: A scoping review. [PDF]

Digit Health
Persson DR, Andersen TO.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Micro/Nano-Reconfigurable Robots for Intelligent Carbon Management in Confined-Space Life-Support Systems. [PDF]

Nanomicro Lett
Lu W, Chen R, Zhan L, Xiang Q, Huang R, Wang L, Wang S, He H.   +7 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Deep learning-based anomaly detection framework for hydraulic support systems in mining safety. [PDF]

Sci Rep
Xin W, Liu L, Wang J, Zheng X.
europepmc   +1 more source