Results 61 to 70 of about 9,444,467 (301)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Wasserstein support vector machine: Support vector machines made fair

European Journal of Operational Research
In this paper, a novel model combining Support Vector Machines (SVM) and equity is introduced. Assuming that a group of individuals need to be protected against discrimination, we address the problem of training the classifier by jointly maximizing the classification performance (SVM margin) and equity (closeness between the distribution of the ...
Emilio Carrizosa, Thomas Halskov, Dolores Romero Morales   +2 more
openaire   +2 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

TEXT CLASSIFICATION BASED ON SUPPORT VECTOR MACHINE

Tạp chí Khoa học Đại học Đà Lạt, 2019
The development of the Internet has increased the need for daily online information storage. Finding the correct information that we are interested in takes a lot of time, so the use of techniques for organizing and processing text data are needed. These
Lê Thị Minh Nguyện
doaj   +1 more source

Functional support vector machine. [PDF]

Biostatistics
Abstract Linear and generalized linear scalar-on-function modeling have been commonly used to understand the relationship between a scalar response variable (e.g. continuous, binary outcomes) and functional predictors. Such techniques are sensitive to model misspecification when the relationship between the response variable and the ...
Xie S, Ogden RT.
europepmc   +3 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

KLASIFIKASI SMS SPAM MENGGUNAKAN SUPPORT VECTOR MACHINE

Pilar Nusa Mandiri, 2019
It is now common for a cellphone to receive spam messages. Great number of received messages making it difficult for human to classify those messages to Spam or no Spam.
Agus Setiyono, Hilman F Pardede
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

SUPPORT VECTOR MACHINE FOR HYDRAULIC SUPPORT RELIABILITY PREDICTION

Jixie qiangdu, 2017
In order to enhance the competitiveness of the domestic hydraulic support. It is imperative to carry out reliability engineering. The reliability evaluation of the hydraulic support in service can effectively provide reference for the development and ...
DING Fei, WANG Qian, ZHANG LiRong, WANG ChunHua   +3 more
doaj