Results 51 to 60 of about 326,273 (311)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Stream Flow Forecasting Using Least Square Support Vector Regression [PDF]

open access: yesJournal of Soft Computing in Civil Engineering, 2018
Accurate forecasting of streamflow for different lead-times is useful in the design of almost all hydraulic structures. The Support Vector Machines (SVMs) use a hypothetical space of linear functions in a kernel-induced higher dimensional feature space ...
Shreenivas Londhe, Seema Gavraskar
doaj   +1 more source

Robust ASR using Support Vector Machines [PDF]

open access: yes, 2007
The improved theoretical properties of Support Vector Machines with respect to other machine learning alternatives due to their max-margin training paradigm have led us to suggest them as a good technique for robust speech recognition. However, important
F. Díaz-de-María   +17 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Support Vector Regression Based S-transform for Prediction of Single and Multiple Power Quality Disturbances [PDF]

open access: yes, 2009
This paper presents a novel approach using Support Vector Regression (SVR) based S-transform to predict the classes of single and multiple power quality disturbances in a three-phase industrial power system.
Mohamed , Azah   +3 more
core  

RSVM: Reduced Support Vector Machines

open access: yes, 2001
An algorithm is proposed which generates a nonlinear kernel-based separating surface that requires as little as 1% of a large dataset for its explicit evaluation.
Olvi L. Mangasarian   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Grey Support Vector Regression Model with Applications to China Tourists Forecasting in Taiwan [PDF]

open access: yes, 2014
Support vector regression (SVR) has been successful in function approximation for forecasting analysis based on the idea of structural risk minimization.
Tsaur, Ruey-Chyn; Chan, Shu-Feng
core   +1 more source

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