Results 241 to 250 of about 2,659,694 (301)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Advancing Toward the UNAIDS 95-95-95 Targets in Sierra Leone: A Narrative Review of Progress, Persistent Gaps, and Policy Priorities. [PDF]

Ann Glob Health
Osborne A, Kamara IF, Lakoh S, Mustapha M, Vandy A, Vandi M, Tengbe SM, Sankoh O.   +7 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Time to viral load suppression after enhanced adherence counseling among HIV patients attending antiretroviral therapy in Southwest Ethiopia. [PDF]

BMC Infect Dis
Berihun H, Felege A, Girma D.
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Porphyromonas gingivalis Suppresses Interferon-Gamma Signaling in Macrophages Through a Contact-Dependent, Gingipain-Mediated Mechanism. [PDF]

Microbiologyopen
Abe S, Ohshima J, Morita M, Tanaka N, Hayashi M.   +4 more
europepmc   +1 more source

Carry-over effect of learned distractor suppression on visual working memory. [PDF]

Front Neurosci
George N, Patel PC.
europepmc   +1 more source

Liver-Specific Suppression of PLA2G6/iPLA₂β Improves Glucose and Lipid Metabolism in High-Fat Diet-Fed Mice. [PDF]

FASEB J
Shimizu K, Nishibata M, Nagata K, Hori S, Michinaga S, Kanehara M, Hashimoto-Iwasaki M, Sakurai F, Shindou H, Tomita K, Nishinaka T, Mizuguchi H.   +11 more
europepmc   +1 more source

Longitudinal analysis of viral suppression before, during, and after pregnancy among women on antiretroviral therapy in Uganda: six-year real-world experience. [PDF]

HIV Res Clin Pract
Ankunda C, Emunyu J, Namasambi S, Kyomuhangi B, Sserunjogi C, Mumbere I, Nakawesi J.   +6 more
europepmc   +1 more source