Results 61 to 70 of about 3,671 (216)

Next Generation Hosts for Protein Recognition, Assembly and More

Chemistry – A European Journal, EarlyView.
The original design of synthetic receptors for proteins was based on macrocycles with a hydrophobic core and a polar/charged periphery. This design, geared towards protein recognition, facilitates receptor self‐assembly. Macrocycle oligomerization, in turn, contributes to protein assembly as evidenced in many cocrystal structures.
Peter B. Crowley
wiley   +1 more source

Engineering and manufacturing of pharmaceutical co-crystals : a review on solvent-free manufacturing technologies [PDF]

, 2016
Design and synthesis of pharmaceutical cocrystals have received great interest in the recent years. Cocrystallization of drug substances offer a tremendous opportunity for the development of new drug products with superior physical and pharmacological ...
Douroumis, D., Lamprou, D. A., Ross, S. A.   +2 more
core   +1 more source

Learning Strategies from Nature's Blueprint to Cyclic Carbonate Synthesis

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
The development of sustainable synthetic methods for cyclic carbonates draws inspiration from nature, focusing on eco‐friendly processes and renewable resources like CO2 and biomass. This review explore various CO2 activation mechanisms, green chemistry principles, and green catalysts.
Erika Saccullo, Vincenzo Patamia, Chiara Zagni, Antonio Rescifina, Giuseppe Floresta   +4 more
wiley   +1 more source

4-[(E)-(5-tert-Butyl-2-hydroxyphenyl)diazenyl]benzoic acid benzene hemisolvate

Acta Crystallographica Section E, 2010
The title benzene hemisolvate, C17H18N2O3·0.5C6H6, features an essentially planar (the r.m.s. deviation of the non-H atoms, excluding methyl-C, is 0.071 Å) diazo molecule with an E conformation about the N=N bond, and a half ...
Edward R. T. Tiekink, Anup Paul, Tushar S. Basu Baul   +2 more
doaj   +1 more source

Designing Heat-Set Gels for Crystallizing APIs at Different Temperatures: A Crystal Engineering Approach

ChemEngineering, 2022
An organic salt crystallizes through different kinds of charge-assisted hydrogen-bonded networks depending on carboxylic functionality number and the degree of amine.
Pathik Sahoo
doaj   +1 more source

Hydrogen-bonding synthons in lamotrigine salts: 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazin-2-ium 2-[(2-carboxyphenyl)disulfanyl]benzoate in its monohydrate and anhydrous forms [PDF]

, 2016
Lamotrigine is a drug used in the treatment of epilepsy and related convulsive diseases. The drug in its free form is rather inadequate for pharmacological use due to poor absorption by the patient, which limits its bioavailability.
Baggio, Ricardo Fortunato, Freire Espeleta, Eleonora, Polla, Griselda Ines   +2 more
core   +1 more source

Mechanistic Paths for the Gold(I)‐Catalyzed Heteroannulation of Salicylic Amides With Apolar Alkynes Explored With Density Functional Theory Calculations

European Journal of Organic Chemistry, EarlyView.
A manifold of catalytic reaction paths can operate in the Au(I)‐catalyzed heteroannulation of salicylic amides and alkynes. However, a subtle initial nucleophilic advantage of N versus O and a kinetic bottleneck at an advanced stage of the mechanistic machinery seems to suffice for the reaction to run on a single path and with exquisite selectivity. We
Ioannis Stylianakis, Evaggelia Vlachou, Carlos Silva López, Antonios Kolocouris   +3 more
wiley   +1 more source

7-Chloro-4-[(E)-(3-chlorobenzylidene)hydrazinyl]-1λ4-quinolinium 3-chlorobenzoate

Acta Crystallographica Section E, 2009
The title salt, C16H12Cl2N3+·C7H4ClO2−, features a non-planar cation, the dihedral angle between the quinolinium and benzene residues being 18.98 (10)°.
James L. Wardell, Edward R. T. Tiekink, R. Alan Howie, Marcus V. N. de Souza, Solange M. S. V. Wardell   +4 more
doaj   +1 more source

Ortho-Fluorination of azophenols increases the mesophase stability of photoresponsive hydrogen-bonded liquid crystals [PDF]

, 2018
Photoresponsive liquid crystals (LCs) whose alignment can be controlled with UV-Visible light are appealing for a range of photonic applications. From the perspective of exploring the interplay between the light response and the self-assembly of the ...
Ahmed Z., Giese M., Kuntze K., Priimagi A., Saccone M., Siiskonen A.   +5 more
core   +1 more source

Triptindane‐9,10,11‐triol: Threefold Hydride Transfer from Lithium Aluminum Hydride as the Key Step to C3‐Symmetrically Trifunctionalized Tribenzo[3.3.3]propellanes

European Journal of Organic Chemistry, EarlyView.
Threefold reduction of 9,10,11‐triptindanetrione with LiAlH4 or NaBH4 yields exclusively the C3‐symmetric triol, suggesting an intracomplex (“rolling”) mechanism. However, use of LiAlH4/LiAlD4 (1 : 1) reveals a preceding hydride exchange. Mechanistic implications are discussed including the reduction of the related diketone.
Thorsten Hackfort, Bernhard M. Malorny, Andreas Mix, Beate Neumann, Hans‐Georg Stammler, Dietmar Kuck   +5 more
wiley   +1 more source