Results 101 to 110 of about 56,017 (267)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Género; Colonialidad; Política pública; Salud; Sur global
, 2022 RESUMEN: Se propone un análisis de políticas públicas que articulan género y salud en América Latina, para repensar la dimensión global de la construcción de conceptos, indicadores e instrumentos de evaluación de impactos de estas políticas en la región.
López, Laura Cecilia +2 more
openaire +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Los estudios comparativos en el campo de la investigación urbana*
Estudios Demográficos y UrbanosEste trabajo examina el papel del método comparativo en la investigación urbana, prestando atención a su utilidad en la generación de teoría, y a las particularidades de las comparaciones entre ciudades de distintas regiones.
Martha Schteingart, Andrés Sierra
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
L'empreinte des états d’urgence sur la loi sur la "sécurité globale"
, 2022 Si la loi pour une sécurité globale n’est pas un régime d’état d’urgence, on sait en revanche que les états d’urgence ont tendance à se pérenniser et à se banaliser en contaminant le droit commun notamment par la reprise des mesures d’état d’urgence dans la loi ordinaire, particulièrement en France, dans le Code de la sécurité intérieure .
openaire +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
De CINVA a Siyabuswa: el trayecto errático de la vivienda de autoayuda global
ARQEn un proyecto piloto para la futura capital Bantustán en Siyabuswa, el estado sudafricano de la era del apartheid financió la investigación y construcción de 59 viviendas básicas entre 1977 y 1978, antes de frenar el esquema completo.
Hannah le Roux
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source