Marine Invertebrate-Associated Bacteria In Coral Reef Ecosystems As A New Source Of Bioactive Compounds [PDF]
, 2004 Coral reefs are the most species-rich environments in the oceans. Reefs cover 0.2% of the ocean’s area and yet they provide home to one-third of marine fishes and to tens of thousands of other species.
Karna Radjasa , Ocky
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Role of Surface Active Agents in Transferosome for Systemic Drug Delivery
Al-Mustansiriyah Journal of Pharmaceutical SciencesThe recent utilization of transferosomes (a type of vesicular drug-carrier system) has shown promising results in enhancing the transport of drugs through the skin when administered topically.
Mohsin Hussein Abdulameer +2 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Transportation Development Division, Active Transportation Section, March 1, 2013 [PDF]
, 2013 This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on April 11, 2014)Mode of ...
core
The Jones-Ray Effect Is Not Caused by Surface Active Impurities [PDF]
, 2018 Pure aqueous electrolyte solutions display a minimum in surface tension at concentrations of ~ 2 mM. This effect has been a source of controversy since first reported by Jones and Ray in the 1930s.
Sylvie, Roke +4 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Sargassum polyceratium (Phaeophyceae, Fucaceae) surface molecule activity towards fouling organisms and embryonic development of benthic species [PDF]
, 2011 International audienceCoral reefs have undergone profound ecological changes over recent decades. Areas formerly covered by scleractinian coral species are now often overgrown by macroalgae.
Hellio, Claire +9 more
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