Results 91 to 100 of about 22,517 (202)

Osmotic Remodeling of Extracellular Vesicles for Precision Nanomedicine

Small, EarlyView.
Hypotonic lysis in bidistilled water is used to remodel B lymphocyte–derived extracellular vesicles into cargo‐depleted, structurally preserved nanovesicles. The process reduces intraluminal proteins and nucleic acids, reshapes membrane composition, and enhances tumor‐cell uptake in vitro, while allowing proof‐of‐concept reloading with exogenous agents,
Francesca Susa, Lorenzo Arnaboldi, Veronica De Giorgis, Marco Ghirimoldi, Elettra Barberis, Marco Brucale, Francesco Valle, Mario Malerba, Marta Vallino, Angelo Musicò, Roberto Frigerio, Alessandro Gori, Vera Mugoni, Claudia Voena, Roberto Pisano, Fabrizio Pirri, Silvia Arpicco, Marcello Manfredi, Tania Limongi   +18 more
wiley   +1 more source

Climate‐Modulated Particle Toxicity: Acute Exposure to an Environmentally Informed Microplastic Mixture Induces Sex‐Dependent Systemic Reorganization in Swiss Mice

Environmental Toxicology, EarlyView.
ABSTRACT Microplastic (MP) pollution is widely recognized as an emerging environmental threat. Yet, most studies still rely on controlled experimental conditions that poorly reflect environmental complexity, potentially underestimating risks under realistic scenarios, particularly during short‐term exposures. Here, we tested whether acute oral exposure
Guilherme Malafaia, Rafaela Ribeiro de Brito, Aline Sueli de Lima de Rodrigues, Omar Cruz Santiago, Andrés Hugo Arias, Thiarlen Marinho da Luz   +5 more
wiley   +1 more source

Abiotic variables drive different aspects of fish community trait variation and species richness across the continental United States

Journal of Animal Ecology, EarlyView.
Trait distributions provide insight into how niches overlap within a broader trait space. By integrating individual‐level trait observations from different communities, we can explore how facets of trait dimensionality vary across environmental conditions.
Alicia McGrew, Crysta Gantz, Brigid Wills, Benjamin Baiser, Sydne Record, Phoebe L. Zarnetske, Angela L. Strecker   +6 more
wiley   +1 more source

Surface based morphometry in alzheimer`s disease

, 2020
Alzheimer's disease (AD) is a neurodegenerative disorder especially affecting the elderly population which is growing worldwide. In this study, surface-based morphometry analysis was performed on anatomical MR images of patients with Alzheimer's Disease (AD) and healthy control (HC) subjects using a computational anatomy toolbox called CAT ...
openaire   +1 more source

Altered surface-based brain morphometry in type 1 diabetes and neuropathic pain

Neuroscience
This study explored surface brain morphometry in type 1 diabetes including focus on painful diabetic peripheral neuropathy (DPN). Brain MRI was obtained from 56 individuals with diabetes (18 without DPN, 19 with painless DPN, 19 with painful DPN) and 20 healthy controls.
Hostrup, Søren NF.; id_orcid 0009-0000-0997-5590, Croosu, Suganthiya S.; id_orcid 0000-0003-0299-8962, Røikjer, Johan; id_orcid 0000-0002-4578-1328, Mørch, Carsten D.; id_orcid 0000-0001-6693-2028, Ejskjær, Niels, Hansen, Tine M.; id_orcid 0000-0002-6160-5519, Frøkjær, Jens B.; id_orcid 0000-0001-8722-0070   +6 more
openaire   +2 more sources

Associations of cannabis use, tobacco use and co‐use with brain volume: A systematic review and meta‐analysis

Addiction, EarlyView.
Abstract Background and aims Cannabis is the most widely used illicit drug worldwide and is often co‐used with tobacco, the leading cause of preventable death. Although cannabis and tobacco have distinct neurobiological actions, their associations with brain volumes are unclear.
Katherine Sawyer, Tom P. Freeman, Martine Skumlien, Esther Walton, Thomas Lancaster, Jorien L. Treur, Valentina Lorenzetti, Anna K. M. Blackwell, Chloe Burke, Richie J. Carr, Constantinos Constantinides, Maisie Cox, Sarah Dance, Shadi Daryan, Sorcha Hamilton, Tom Jenkins, Gemma M. J. Taylor   +16 more
wiley   +1 more source

Depressive disorders are associated with brain structural injury in HIV-positive men who have sex with men

BMC Psychiatry
Background Depressive disorders (DD) are more prevalent among people with HIV (PWH) compared to the general population. Research in the general population has confirmed the association between depression and gray matter atrophy as well as reduced ...
Yihui He, Wen Wang, Ping Wu, Guangqiang Sun, Yundong Ma, Miaotian Cai, Letian Liu, Yanmin Liu, Lei Wang, Yulin Zhang, Cheng Wan, Tong Zhang, Yang Zhang   +12 more
doaj   +1 more source

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Chronic spinal cord injury is associated with morphometric brain changes in functional networks beyond the sensorimotor system

Frontiers in Neurology
IntroductionSpinal cord injury (SCI) leads to motor and sensory deficits, triggering widespread neurodegeneration across the central nervous system.
Lorenzo Diana, Jothini Sritharan, Jothini Sritharan, Vanessa Vallesi, Vanessa Vallesi, Nicola Brunello, Nicola Brunello, Rajeev K. Verma, Rajeev K. Verma, Rajeev K. Verma, Giuseppe A. Zito, Giuseppe A. Zito   +11 more
doaj   +1 more source

Cellular Dynamics and Dentine Bridge Formation Following Direct Pulp Capping With MTA and Biodentine in a Murine Model

International Endodontic Journal, EarlyView.
ABSTRACT Aim Formation of a mineralized dentine bridge is the hallmark of successful direct pulp capping (DPC). Mineral trioxide aggregate (MTA) and Biodentine are widely used capping materials, but in vivo evidence comparing their regenerative potential remains inconclusive. This study used a controlled murine model to compare dentine bridge formation
Amnah Sajdeya, Joshua Milgram, Nurit Kot‐Limon, Itzhak Abramovitz, Amnon Sharir   +4 more
wiley   +1 more source