Results 131 to 140 of about 7,208,381 (319)
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Development of an automatic surface finishing system (ASFS) with in-process surface topography inspection [PDF]
, 2010 This paper describes an automated surface finishing system (ASFS) with in-process surface topography inspection. The acquired surface topography feedback is used to calculate the surface error and to generate the finishing paths for each level of surface
陳炤彰; Chen, Chao-chang A.; Duffie, Neil A.
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Continuous meteorological surface measurement during Alexander von Humboldt cruise 07AL991_3 [PDF]
, 2006 Continuous meteorological surface measurement during Alexander von Humboldt cruise ...
WOCE Surface Meteorology Data, WOCEMET +3 more
core +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Spalva naujojoje Vilniaus architektūroje
Journal of Architecture and Urbanism, 2009 This paper attempts to make a review of reasons for the use of colour, bringing together the guidelines for the analysis of colour in architectural composition and analysing the use of colour in the new Vilnius architecture during the first years of the ...
Romualdas Kučinskas
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Journal of the Mechanical Behavior of Materials, 2012 Superhydrophobicity – also known as water repellency – has recently attracted considerable attention because of its numerous potential applications. However, the fundamental concepts and equations describing the wettability of superhydrophobic surfaces ...
Karapanagiotis Ioannis +1 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source