Results 41 to 50 of about 3,823 (252)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Zangetsu: A Candidate Isolated, Quiescent, and Backsplash Ultra-diffuse Galaxy in the COSMOS Field

The Astrophysical Journal
Deep imaging surveys have changed our view of the low surface brightness (LSB) Universe. The “renaissance” of the LSB galaxy population, as a prime example of this recent development, continues to challenge our understanding of galaxy formation. Here, we
Leyao Wei, Song Huang, Jiaxuan Li, Zechang Sun, Mingyu Li, Jiaxin Tang   +5 more
doaj   +1 more source

Stellar populations and surface brightness fluctuations: new observations and models [PDF]

Monthly Notices of the Royal Astronomical Society, 2001
24 pages with 17 embedded figures.
Blakeslee, John P., Vazdekis, Alexandre, Ajhar, Edward A.   +2 more
openaire   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

ON THE NATURE OF X-RAY SURFACE BRIGHTNESS FLUCTUATIONS IN M87 [PDF]

The Astrophysical Journal, 2016
ABSTRACT X-ray images of galaxy clusters and gas-rich elliptical galaxies show a wealth of small-scale features that reflect fluctuations in density and/or temperature of the intracluster medium. In this paper we study these fluctuations in M87/Virgo to establish whether sound waves/shocks, bubbles, or uplifted cold gas dominate the ...
P. Arévalo, E. Churazov, I. Zhuravleva, W. R. Forman, C. Jones   +4 more
openaire   +3 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Surface brightness fluctuation distances for nearby dwarf elliptical galaxies [PDF]

Astronomy & Astrophysics, 2001
We obtained B and R-band CCD images for the dwarf elliptical (dE) galaxies DDO44, UGC4998, KK98_77, DDO71, DDO113, and UGC7356 at the NOT. Using Fourier analysis technique we measure stellar R-band surface brightness fluctuations (SBFs) and magnitudes in 29 different fields of the galaxies.
Jerjen, Helmut, Rekola, R, Takalo, L, Coleman, Matthew, Valtonen, M   +4 more
openaire   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Assessment and Correction of Calibration Consistency in Medium Resolution Imagers’ Split-Window Channels Using Dome C

IEEE Access
Accurate radiometric calibration consistency is fundamental for quantitative remote sensing retrievals using multi-source sensors. Previous studies have mainly evaluated inter-sensor calibration consistency (e.g., MODIS and VIIRS) but lacked systematic ...
Wenbin Tian, Cailan Gong, Yang Wang, Yong Hu, Fuqiang Zheng   +4 more
doaj   +1 more source