Results 41 to 50 of about 3,858 (229)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Assessment and Correction of Calibration Consistency in Medium Resolution Imagers’ Split-Window Channels Using Dome C

IEEE Access
Accurate radiometric calibration consistency is fundamental for quantitative remote sensing retrievals using multi-source sensors. Previous studies have mainly evaluated inter-sensor calibration consistency (e.g., MODIS and VIIRS) but lacked systematic ...
Wenbin Tian, Cailan Gong, Yang Wang, Yong Hu, Fuqiang Zheng   +4 more
doaj   +1 more source

Surface brightness fluctuations and the distance to the Virgo Cluster

The Astrophysical Journal, 1989
Preliminary results from a project to measure the fluxes of giant stars in M32, NGC 3379, and five Virgo Cluster galaxies are presented. Since the Virgo Cluster galaxies are approximately equidistant, variations in observed fluctuation amplitude from galaxy to galaxy can be ascribed to variations in absolute luminosity of the giant stars in the ...
John L. Tonry, Edward A. Ajhar, Gerard A. Luppino   +2 more
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Surface Brightness Fluctuations

The Surface Brightness Fluctuation (SBF) method is a powerful tool for determining distances to early-type galaxies. The method measures the intrinsic variance in a galaxy's surface brightness distribution to determine its distance with an accuracy of about 5%.
Cantiello, Michele, Blakeslee, John P.
openaire   +2 more sources

The Infrared Surface Brightness Fluctuation Hubble Constant

The Astrophysical Journal, 2001
We measured infrared surface brightness fluctuation (SBF) distances to an isotropically-distributed sample of 16 distant galaxies with redshifts reaching 10,000 km/s using the near-IR camera and multi-object spectrometer (NICMOS) on the Hubble Space Telescope (HST).
Jensen, Joseph B., Tonry, John L., Thompson, Rodger I., Ajhar, Edward A., Lauer, Tod R., Rieke, Marcia J., Postman, Marc, Liu, Michael C.   +7 more
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The Next Generation Virgo Cluster Survey (NGVS). III. A Catalog of Surface Brightness Fluctuation Distances and the Three-dimensional Distribution of Galaxies in the Virgo Cluster

The Astrophysical Journal
The surface brightness fluctuation (SBF) method is a robust and efficient way of measuring distances to galaxies containing evolved stellar populations. Although many recent applications of the method have used space-based imaging, SBF remains a powerful
Michele Cantiello, John P. Blakeslee, Laura Ferrarese, Patrick Côté, Gabriella Raimondo, Jean-Charles Cuillandre, Patrick R. Durrell, Stephen Gwyn, Nandini Hazra, Eric W. Peng, Joel C. Roediger, Rúben Sánchez-Janssen, Max Kurzner   +12 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A Possible “Too-many-satellites” Problem in the Isolated Dwarf Galaxy DDO 161

The Astrophysical Journal Letters
The abundance of satellite galaxies provides a direct test of ΛCDM and galaxy formation physics on small scales. While satellites of Milky Way-mass galaxies are well studied, those of dwarf galaxies remain largely unexplored.
Jiaxuan Li, Jenny E. Greene, Shany Danieli, Scott G. Carlsten, Marla Geha   +4 more
doaj   +1 more source