Results 81 to 90 of about 410,681 (239)

Resolving Gamma-Ray Burst 000301C with a Gravitational Microlens [PDF]

, 2000
The afterglow of the Gamma-Ray Burst (GRB) 000301C exhibited achromatic, short time-scale variability that is difficult to reconcile with the standard relativistic shock model.
Abraham Loeb, Chang K., K. Z. Stanek, Masetti N., Peter M. Garnavich   +4 more
core   +4 more sources

A comparison of the planetary nebula luminosity function and surface brightness fluctuation distance scales

, 1993
Two of the best techniques for measuring distances greater than ∼3 Mpc are the planetary nebula luminosity function (PNLF) and the surface brightness fluctuation (SBF) method.
R. Ciardullo, G. Jacoby, J. Tonry
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Analytical and Monte Carlo results for the surface-brightness diameter relationship in supernova remnants [PDF]

published on Apj 746 , 56 (2012), 2012
The surface brightness diameter relationship for supernovae remnants (SNRs) is explained by adopting a model of direct conversion of the flux of kinetic energy into synchrotron luminosity. Two laws of motion are adopted, a power law model for the radius-time relationship, and a model which uses the thin layer approximation.
arxiv   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Surface Brightness Fluctuations

The Surface Brightness Fluctuation (SBF) method is a powerful tool for determining distances to early-type galaxies. The method measures the intrinsic variance in a galaxy's surface brightness distribution to determine its distance with an accuracy of about 5%.
Cantiello, Michele, Blakeslee, John P.
openaire   +2 more sources

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

First Assessment of SDGSAT-1 TIS Thermal Infrared Bands Calibration Using Landsat 9 TIRS-2

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
SDGSAT-1, the inaugural Earth science satellite commissioned by the Chinese Academy of Sciences, successfully lifted off from China's Taiyuan Satellite Launch Center on 5 November 2021. Cross calibration has emerged as an indispensable methodology,
Min Zhu, Qiyao Wang, Jianing Yu, Zhuoyue Hu, Fansheng Chen   +4 more
doaj   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source