Results 141 to 150 of about 6,734,388 (302)

Modelling and optimisation of the surface‐mounted permanent magnet machine with multi‐level array magnets

IET Electric Power Applications
An analytical and optimisation method is presented to improve the air‐gap magnetic field of the surface‐mounted permanent magnet machine with multi‐level array magnets, which can reduce air‐gap magnetic field harmonics and torque ripple.
Longxuan Li, Zhaoliang Chen, Wenliang Zhao, Chengwu Diao, Byung‐il Kwon   +4 more
doaj   +1 more source

Modification of Surface Fluxes from Component Models in Global Coupled Models

Journal of Climate, 1997
Abstract The present generation of global coupled ocean–atmosphere GCMs contains considerable systematic errors both in terms of net surface heat flux and simulated SSTs. Here, a global coupled GCM is used to illustrate how systematic errors in the separate coupled model components (atmosphere and ocean) contribute to the simulations of net surface ...
openaire   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

High-resolution ensemble LES energy balance closure study of the LITFASS-2003 campaign

Meteorologische Zeitschrift
The imbalance between the measured available energy and the sum of the turbulent fluxes lead to the energy balance closure problem. In spite of several experimental and modelling studies, the reasons for the lack of closure are not fully understood ...
Sadiq Huq, Frederik De Roo, Matthias Sühring, Luise Wanner, Matthias Mauder   +4 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

A flux tower site attribute dataset intended for land surface modeling

Earth System Science Data
Abstract. Land surface models (LSMs) should have reliable forcing, validation, and surface attribute data as the foundation for effective model development and improvement. Eddy covariance flux tower data are considered the benchmarking data for LSMs.
Jiahao Shi, Hua Yuan, Wanyi Lin, Wenzong Dong, Hongbin Liang, Zhuo Liu, Jianxin Zeng, Haolin Zhang, Nan Wei, Zhongwang Wei, Shupeng Zhang, Shaofeng Liu, Xingjie Lu, Yongjiu Dai   +13 more
openaire   +4 more sources

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Integrating Remotely Sensed Thermal Observations for Calibration of Process-Based Land-Surface Models: Accuracy, Revisit Windows, and Implications in a Dryland Ecosystem

Remote Sensing
Understanding land surface fluxes is essential for sustaining dryland ecosystem functioning and services. However, the scarcity of in situ measurements poses a significant challenge to dryland monitoring. Satellite optical and thermal remote sensing data
Arnau Riba, Monica Garcia, Ana M. Tarquís, Francisco Domingo, Michal Antala, Sijia Feng, Jun Liu, Mark S. Johnson, Yeonuk Kim, Sheng Wang   +9 more
doaj   +1 more source