Results 31 to 40 of about 113,357 (317)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Assessing Different Feature Sets’ Effects on Land Cover Classification in Complex Surface-Mined Landscapes by ZiYuan-3 Satellite Imagery

Remote Sensing, 2017
Land cover classification (LCC) in complex surface-mined landscapes has become very important for understanding the influence of mining activities on the regional geo-environment.
Weitao Chen, Xianju Li, Haixia He, Lizhe Wang   +3 more
doaj   +1 more source

Autonomous and Operator-Assisted Electric Rope Shovel Performance Study

Mining, 2022
Automation has been changing the mining industry for the past two decades. Material handling is a critical task in a mining operation, and truck-shovel handling systems are the primary method for surface mining. Mines have deployed autonomous trucks, and
Ali Yaghini, Robert Hall, Derek Apel
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Mapping the Spatiotemporal Patterns of Surface Mining in Resource-Based Cities and Assessing Their Impact on Land Surface Temperature Across the Urban–Rural Gradient

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Intensive mining activities in resource-based cities can significantly alter the local thermal environment. However, due to the dynamic characteristics and heterogeneous backgrounds of mining areas, it remains challenging to delineate their ...
Xiaoquan Pan, Zilong Xia, Hong Fang, Haowei Mu, Bo Yuan, Shanchuan Guo, Peijun Du   +6 more
doaj   +1 more source

Electrochemical Evaluation of Compressed Selective Laser Melted AlSi7Mg and AlSi10Mg Alloys in Chloride Environment

Advanced Engineering Materials, EarlyView.
The corrosion performance of AlSi7Mg and AlSi10Mg alloys produced through selective laser melting (SLM) was examined under compressive stress in a chloride environment. Electrochemical analyses, including open‐circuit potential (OCP), potentiodynamic polarization (CPP), and electrochemical impedance spectroscopy (EIS), were complemented by scanning ...
Femi John Akinfolarin, Samson Dare Oguntuyi, Peter Apata Olubambi   +2 more
wiley   +1 more source

Effects of mining subsidence observed by time-lapse seismic reflection profiling [PDF]

, 1995
Extracting coal from underground mineworkings causes the overlying rocks to subside with associated changes in the stress regime. The aim of the study reported here was to apply the surface seismic reflection method to study the effect of subsidence on ...
Al-Rawahy, Salim Y.S.
core  

Innovative Processing of Compacted Waste Aluminum Alloy Powders via Controlled Remelting and Solidification

Advanced Engineering Materials, EarlyView.
This study demonstrates an efficient recycling route for out‐of‐spec AlSi10Mg atomized powders through compaction and arc remelting followed by suction casting. By correlating compaction load, cooling rate, and resulting microstructure, we show that intermediate pressures (50–80 kN) and rapid cooling refine dendrites, reduce porosity, and enhance ...
Mila Christy de Oliveira, Marcella Gaute Cavalcante Xavier, Abdoul‐Aziz Bogno, Piter Gargarella, José Eduardo Spinelli   +4 more
wiley   +1 more source

Deep sublevel cave mining and surface influence

, 2017
With increasing mining depths and excavation volumes comes not only increased rock stresses and more difficult underground mining conditions, but also increased surface effects, in particular from cave mining.
Storvall, Erik,, Lope Alvarez, Diego,, Fredrick Perman, Diego Lope Alvarez, Sjöberg, Jonny,, Mäkitaavola, Karola,, Erik Storvall, Britt-Mari Stöckel, Karola Mäkitaavola, Perman, Fredrick,, Thierry Lavoie, Stöckel, Britt-Marie,, Jonny Sjöberg, Lavoie, Thierry,   +13 more
core   +1 more source