IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Enhanced electrical conductivity of TiO<sub>2</sub> micro-rods through surface modification by antimony-doped tin oxide. [PDF]
Son YS, Pawar AU, Lee DK, Kang YS.
europepmc +1 more source
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
Hydrophobic Ion Pairing Improves Protein Thermal Stability and Lipid Nanocarrier Integration through Controlled Surface Modification. [PDF]
Mu J +3 more
europepmc +1 more source
Universal Microfluidic Platform for Multifunctional Surface Modification of Small Extracellular Vesicles. [PDF]
Hong Y +11 more
europepmc +1 more source
Acidity-Mediated Metal Oxide Heterointerfaces: Roles of Substrates and Surface Modification. [PDF]
Lee GR +5 more
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Chemical Surface Modification Tolerance of Primary and Immortalized Macrophages and Stem Cells. [PDF]
Winters KJ +5 more
europepmc +1 more source
Nature-Inspired Surface Modification Strategy Reverses the Autophagic Flux Impairment of Mitochondrial Transplantation for Attenuating Ischemic Strokes. [PDF]
Wang N +12 more
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Surface Modification of Cranioplasty Implants to Reduce Postoperative Cerebrospinal Fluid Collection: A Preliminary Clinical Study. [PDF]
Kim TY, Lee MH.
europepmc +1 more source

