Advanced Science, EarlyView.This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong +15 more
wiley +1 more source
Self-referencing surface plasmon sensor for resolution enhancement. [PDF]
Sci RepKohandani R, Saini S.
europepmc +1 more source
DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition
Advanced Science, EarlyView.A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao +8 more
wiley +1 more source
A Novel Surface Plasmon Resonance Imaging (SPRi) Biosensor for the Determination of Bovine Interleukin-10: Development, Validation, and Application in Biological Fluids. [PDF]
Int J Mol SciPytel A +7 more
europepmc +1 more source
Advanced Science, EarlyView.This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao +13 more
wiley +1 more source
Surface-plasmon control of ultrafast energy-relaxation modes in photoexcited Au nanorods probed by time-resolved single-particle X-ray imaging. [PDF]
Nat CommunPark E +14 more
europepmc +1 more source
Compact Sensing Platforms Based on Localized Surface Plasmon Resonance
, 2018 Zhutian Ding
openalex +1 more source
Advanced Science, EarlyView.Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan +11 more
wiley +1 more source
Design of a Photonic Crystal Fiber Optic Magnetic Field Sensor Based on Surface Plasmon Resonance. [PDF]
Sensors (Basel)Yi Y +6 more
europepmc +1 more source
Surface Plasmon Resonance Biosensors Based on High-Index Dielectric Metal-Insulator-Metal Structures
, 2018 Sarah Clark
openalex +1 more source