Results 61 to 70 of about 4,224,482 (302)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The energetics of water on oxide surfaces by quantum Monte Carlo

, 2006
Density functional theory (DFT) is widely used in surface science, but gives poor accuracy for oxide surface processes, while high-level quantum chemistry methods are hard to apply without losing basis-set quality.
Alfe`, D., Gillan, M. J.
core   +1 more source

Advanced enzyme-assembled hydrogels for the remediation of contaminated water

Nature Communications
Enzyme-catalyzed biodegradation is an emerging green strategy for environmental remediation, although challenged by high cost and poor robustness.
Jinlong Zhang, Jason C. White, Gregory V. Lowry, Jinglei He, Xuefeng Yu, Chuanhao Yan, Liang Dong, Shu Tao, Xilong Wang   +8 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Regimes of Precursor-Mediated Epitaxial Growth [PDF]

, 2007
A discussion of epitaxial growth is presented for those situations (OMVPE, CBE, ALE, MOMBE, GSMBE, etc.) when the kinetics of surface processes associated with molecular precursors may be rate limiting. Emphasis is placed on the identification of various
Vvedensky, D. D., Zangwill, A.
core   +1 more source

Relationships Between Evacuation Population Size, Earthquake Emergency Shelter Capacity, and Evacuation Time

International Journal of Disaster Risk Science, 2017
Determining the location of earthquake emergency shelters and the allocation of affected population to them are key issues that face shelter planning and emergency management.
Xiujuan Zhao, Wei Xu, Yunjia Ma, Lianije Qin, Junlin Zhang, Ying Wang   +5 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Influence of hydrodynamic processes on the fate of sedimentary organic matter on continental margins [PDF]

, 2018
Understanding the effects of hydrodynamic forcing on organic matter (OM) composition is important for assessment of organic carbon (OC) burial in marginal seas on regional and global scales.
Aller, Aller, Arnarson, Bao, Bao, Bauer, Bianchi, Bianchi, Bianchi, Blair, Blair, Blair, Bröder, Burdige, Burdige, Cameron McIntyre, Canuel, Cartapanis, Cathalot, Chen, Coppola, Cui, Daniel B. Montluçon, Drenzek, Eglinton, Galy, Gao, Goñi, Griffith, Guo, Harris, Hedges, Hilton, Hilton, Hwang, Inthorn, Kao, Keil, Keil, Kusch, Kusch, Leithold, Li, Lie, Liu, Liu, Liu, Liu, Luo, Marwick, Mayer, McCave, McCave, McCave, Meixun Zhao, Milliman, Mollenhauer, Mollenhauer, Mollenhauer, Mollenhauer, Mollenhauer, Mollenhauer, Muller-Karger, Nuwer, Ohkouchi, Pawlowicz, Pedrosa-Pàmies, Qiao, Rui Bao, Saito, Shah, Stuiver, Su, Tao, Tao, Tesi, Tesi, Tesi, Tesi, Tessa S. van der Voort, Thomsen, Thomsen, Timothy I. Eglinton, Voort, Wagner, Wakeham, Wang, Wang, Wang, Wang, Wang, Wang, Wu, Xinyu Guo, Xu, Yang, Yang, Yang, Yang, Yao, Yao, Zhu, Zonneveld   +102 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source