Results 61 to 70 of about 9,664,885 (256)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Advanced enzyme-assembled hydrogels for the remediation of contaminated water
Nature CommunicationsEnzyme-catalyzed biodegradation is an emerging green strategy for environmental remediation, although challenged by high cost and poor robustness.
Jinlong Zhang +8 more
doaj +1 more source
The study of surface processes under electrochemical control in the presence of inertial cavitation [PDF]
, 2005 In some circumstances, the erosive effects of inertial (transient) cavitation have been usefully employed in the acceleration of chemical processes that are dependent on surface reactions.
Birkin, Peter R. +2 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Grinding processes and their effects on surface integrity [PDF]
, 2005 The introduction of high performance grinding machines in combination with the latest superabrasive technology has the potential to impact significantly on existing process chains.
Comley, Paul
core +3 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A statistical process for surface tracking [PDF]
, 1996 This paper describes a novel approach to surface tracking in volumetric image stacks. It draws on a statistical model of the uncertainties inherent in the characterisation of feature contours to compute an evidential field for putative inter-frame displacements.
Nigel G. Sharp, Edwin R. Hancock
openaire +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Innovative analysis and use of high-resolution DTMs for quantitative interrogation of Earth-surface processes [PDF]
, 2014 This is the era of digital landscapes; the widespread availability of powerful sensing technologies has revolutionized the way it is possible to interrogate landscapes in order to understand the processes sculpting them.
P. Passalacqua +8 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source