Results 71 to 80 of about 274,834 (357)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Validation of Space-Based Albedo Products from Upscaled Tower-Based Measurements Over Heterogeneous and Homogeneous Landscapes

Remote Sensing, 2020
Surface albedo is a fundamental radiative parameter as it controls the Earth’s energy budget and directly affects the Earth’s climate. Satellite observations have long been used to capture the temporal and spatial variations of surface albedo
Rui Song, Jan-Peter Muller, Said Kharbouche, Feng Yin, William Woodgate, Mark Kitchen, Marilyn Roland, Nicola Arriga, Wayne Meyer, Georgia Koerber, Damien Bonal, Benoit Burban, Alexander Knohl, Lukas Siebicke, Pauline Buysse, Benjamin Loubet, Montagnani Leonardo, Christophe Lerebourg, Nadine Gobron   +18 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Retrieval of Aerosol Optical Depth in the Arid or Semiarid Region of Northern Xinjiang, China

Remote Sensing, 2018
Satellite remote sensing has been widely used to retrieve aerosol optical depth (AOD), which is an indicator of air quality as well as radiative forcing.
Xinpeng Tian, Sihai Liu, Lin Sun, Qiang Liu   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Directional Applicability Analysis of Albedo Retrieval Using Prior BRDF Knowledge

Remote Sensing
Surface albedo measures the proportion of incoming solar radiation reflected by the Earth’s surface. Accurate albedo retrieval from remote sensing data usually requires sufficient multi-angular observations to account for the surface reflectance ...
Hu Zhang, Qianrui Xi, Junqin Xie, Xiaoning Zhang, Lei Chen, Yi Lian, Hongtao Cao, Yan Liu, Lei Cui, Yadong Dong   +9 more
doaj   +1 more source

Evaluating Environmental Weathering Effects on White Portland Cement using Hyperspectral Reflectance Analysis [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Cement is a primary binding material that plays a crucial role in construction. This study used hyperspectral reflectance analysis to investigate the spectral reflectance characteristics of White Portland Cement (WPC) exposed to environmental conditions.
I. Ahmed, U. K. Sharma, P. K. Garg, A. K. Thakur, Pritipadmaja   +4 more
doaj   +1 more source

Morphological and optical properties of porous hydroxyapatite/cornstarch (HAp/Cs) composites

Journal of Materials Research and Technology, 2020
This paper presents the correlation between the morphological characteristics and the diffuse reflectance (optical properties) of the porous hydroxyapatite/cornstarch (HAp/Cs) composites with various starch proportions (30, 40, 50, 60, 70, 80 and 90 wt%).
C.Y. Beh, E.M. Cheng, N.F. Mohd Nasir, Emma Ziezie Mohd Tarmizi, S.K. Eng, M.S. Abdul Majid, M.J.M. Ridzuan, S.F. Khor, F.S. Ahmad Saad   +8 more
doaj   +1 more source

Ground Reflectance Measurements from Thematic Mapper Data [PDF]

Satellite radiance data are measures of solar radiation that has been reflected by the Earth's surface and scattered and absorbed by atmospheric gases and aerosols. Of concern to geologists are the surface reflectance and the degrading effects on surface
Conel, J. E.
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source