Results 71 to 80 of about 122,922 (297)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?

open access: yesArthritis Care &Research, EarlyView.
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier   +12 more
wiley   +1 more source

Strengthening of Steel Structures with High Modulus Carbon Fiber Reinforced Polymer (CFRP) Materials

open access: yes, 2005
Transportation departments and the telecommunications industry are currently demanding cost-effective rehabilitation and/or strengthening techniques for steel structures, including bridges and monopole towers.
Schnerch, David
core  

Experimental study on strengthening of RC beams with Side Near Surface Mounted technique-CFRP bars

open access: yes, 2020
International audienceThis paper presents an experimental program that was carried out for the purpose of studying the global flexural performance of reinforced concrete beams strengthened internally with Carbon Fiber Reinforced Polymer (CFRP) rods using
Al Mahmoud, Firas   +4 more
core   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

open access: yesAdvanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt   +8 more
wiley   +1 more source

Electrochemical Evaluation of Compressed Selective Laser Melted AlSi7Mg and AlSi10Mg Alloys in Chloride Environment

open access: yesAdvanced Engineering Materials, EarlyView.
The corrosion performance of AlSi7Mg and AlSi10Mg alloys produced through selective laser melting (SLM) was examined under compressive stress in a chloride environment. Electrochemical analyses, including open‐circuit potential (OCP), potentiodynamic polarization (CPP), and electrochemical impedance spectroscopy (EIS), were complemented by scanning ...
Femi John Akinfolarin   +2 more
wiley   +1 more source

Strengthening of oxide glasses : Chapter 3.12

open access: yes, 2021
The ways to strengthen oxide glasses are closely linked with surface defects, which act as stress amplifiers and thus reduce the practical strength of the material.
Karlsson, Stefan,, Wondraczek, Lothar,
core   +1 more source

NFDI MatWerk Ontology (MWO): A BFO‐Compliant Ontology for Research Data Management in Materials Science and Engineering

open access: yesAdvanced Engineering Materials, EarlyView.
This article presents the NFDI‐MatWerk Ontology (MWO), a Basic Formal Ontology‐based framework for interoperable research data management in materials science and engineering (MSE). Covering consortium structures, research data management resources, services, and instruments, MWO enables semantic integration, Findable, Accessible, Interoperable, and ...
Hossein Beygi Nasrabadi   +4 more
wiley   +1 more source

CLASSIFICATION AND PHYSICO-TECHNOLOGICAL ASPECTS OF DYNAMIC METHODS OF SURFACE-PLASTIC DEFORMATION

open access: yesВестник Донского государственного технического университета, 2018
The classification of dynamic methods of the surface plastic deformation is described. Physics of the work hardening mechanism by these methods is revealed from the perspective of the energy approach. The preferred area of their technological application
Valery A. Lebedev
doaj  

Surface integrity after surface strengthening technologies

open access: yes, 2016
Diplomová práce je zaměřena komplexně na kvalitu povrchové vrstvy. Detailněji jsou zpracována drsnost povrchu, zbytková napětí, mikrotvrdost a metalografie.
Vondrák Tomáš
core  

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