SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian +8 more
wiley +1 more source
Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids
This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Ilaria Incaviglia +8 more
wiley +1 more source
Chemical heterogeneity and mixed pollution are associated with microbial functional potential across soils in a coal mining subsidence landscape. [PDF]
Yin Y +10 more
europepmc +1 more source
This work presents a large‐cell‐compatible droplet microfluidic platform that overcomes long‐standing barriers in plant cell culture by enabling high‐fidelity encapsulation, novel multilayer 3D droplet incubation for scalable long‐term culture, and support for the full developmental progression of large plant cells.
Arman Mirmiran +10 more
wiley +1 more source
Anthropogenic and Geogenic Factors Affecting Groundwater Arsenic and Potential Drinking Water Exposure in the San Luis Valley, Colorado. [PDF]
Smith RG +8 more
europepmc +1 more source
Curvature‐Directed Elongation and Chiral Tilting Drive Asymmetric Tissue Patterning
Curvature and cell handedness together break tissue symmetry. On convex and concave surfaces, cells elongate along opposite geometric axes and tilt in a consistent chirality‐driven direction, yielding opposite alignment patterns from the same cells. Reversing intrinsic cell chirality reverses both.
Liyao Xu +6 more
wiley +1 more source
A Multi-Source Remote-Sensing-Assisted Method for GNSS Station Site Selection in Underground Coal-Mining Subsidence Areas. [PDF]
He Y +8 more
europepmc +1 more source
Human water demand constrains China's feasible afforestation potential more strongly than is commonly recognized, and future climate change further intensifies this limitation. Integrating land‐use optimization with water‐saving measures substantially expands feasible afforestation area and associated carbon sinks, revealing a practical pathway to ...
Binbin Huang +5 more
wiley +1 more source
Does the Addition of Locked Cross-Elements Prevent Screw Subsidence Following Locking Plate Fixation of Proximal Humerus Fractures? [PDF]
Lu H +5 more
europepmc +1 more source

