Results 31 to 40 of about 15,178 (240)

Mine Geological Environment Monitoring and Risk Assessment in Arid and Semiarid Areas

Complexity, 2021
Along with the accelerated shift of coal mining to the ecologically fragile west, the contradiction between coal resource development and ecological protection in the western arid and semiarid coal mining areas is rapidly intensifying. Based on the above
Jiaqi Jin, Chicheng Yan, Yixuan Tang, Yilong Yin   +3 more
doaj   +1 more source

Monitoring, analyzing and predicting urban surface subsidence: A case study of Wuhan City, China

International Journal of Applied Earth Observations and Geoinformation, 2021
Wuhan, one of China's megacities with rapid development, is facing serious surface subsidence. In this study, we combined MT-InSAR, geo-detector, and LSTM (Long Short-Term Memory) to achieve the monitoring, analysis, and prediction of surface subsidence ...
Qing Ding, Zhenfeng Shao, Xiao Huang, Orhan Altan, Qingwei Zhuang, Bin Hu   +5 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Detecting, Monitoring, and Analyzing the Surface Subsidence in the Yellow River Delta (China) Combined with CenterNet Network and SBAS-InSAR

Journal of Spectroscopy, 2022
Long-term industrial activities tend to cause surface subsidence and damage to ground facilities and local ecological environment. Monitoring and analyzing surface subsidence is of great significance to prevent potential disasters.
Zhenjin Li, Zhiyong Wang, Wei Liu, Xing Li, Maotong Zhou, Baojing Zhang   +5 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Study on the Surface Subsidence Trend of Fill Mining in Underground Mines With Different Mining Depths

Advances in Civil Engineering
The extraction of underground mineral deposits can cause surface subsidence, which will bring danger to surface buildings or structures. In this paper, the Panlong lead–zinc mine in Guangxi, China, was taken as an example to analyze the correlation ...
Xianyang Qiu, Xiangrui He, Rihong Cao, Hongjie Qiu, Xiuzhi Shi, Yonggang Gou, Xiaoyuan Li, Wei Zhi   +7 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Complex Surface Deformation of the Coalfield in the Northwest Suburbs of Xuzhou from 2015 to 2020 Revealed by Time Series InSAR

Canadian Journal of Remote Sensing, 2021
The coalfield in the northwest suburbs of Xuzhou has suffered from extensive land subsidence; however, the temporal nonlinearity and corresponding spatial variation of its surface deformation has not been adequately explored.
Langping Li, Cunfa Zhao, Jianxue Huang, Changming Huan, Huaqiao Wu, Ping Xu, Linshan Yuan, Yi Chen   +7 more
doaj   +1 more source