Results 51 to 60 of about 9,804,723 (309)

Meteorology and surface energy fluxes in the 2005–2007 ablation seasons at the Miage debris-covered glacier, Mont Blanc Massif, Italian Alps [PDF]

, 2010
During the 2005–2007 June–September ablation seasons, meteorological conditions were recorded on the lower and upper parts of the debris‐covered ablation zone of Miage Glacier, Italy. In 2005, debris temperature and subdebris ice melt were also monitored
Mihalcea, Claudia, Diolaiuti, Guglielmina, G.A. Diolaiuti, Brock, Ben W., Kirkbride, Martin P., M. Kirkbride, C.E. Mihalcea, Cutler, Mark E. J.; id_orcid, C. Smiraglia, M. E. J. Cutler, Cutler, Mark, Brock, Benjamin, Kirkbride, Martin, Smiraglia, Claudio, B. W. Brock   +14 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Decadal-scale reduction in net primary production in the western subarctic North Pacific: impact of lateral transport of dissolved iron from the Sea of Okhotsk

Environmental Research Letters
The subarctic North Pacific (SNP) is a high-nutrient low-chlorophyll region in which decoupling of dissolved iron (dFe) and macronutrient is an essential control of primary production.
Takuya Nakanowatari, Tomohiro Nakamura, Humio Mitsudera, Jun Nishioka, Hatsumi Nishikawa, Hiroshi Kuroda, Keisuke Uchimoto   +6 more
doaj   +1 more source

Effect of surface preparation on the corrosion of austenitic stainless steel 304L in high temperature steam and simulated PWR primary water [PDF]

, 2012
The corrosion behavior of 304L grade stainless steel (SS) in high-temperature steam and in a simulated Pressurized Water Reactor (PWR) is studied. The goal was to characterize the nature of the oxide coating generated during 500 h exposure of samples in ...
Cissé, Sarata, Tanguy, Benoit, Andrieu, Eric, Laffont, Lydia, Lafont, Marie-Christine   +4 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Internal variability of Earth’s energy budget simulated by CMIP5 climate models

Environmental Research Letters, 2014
We analyse a large number of multi-century pre-industrial control simulations from the fifth phase of the Coupled Model Intercomparison Project (CMIP5) to investigate relationships between: net top-of-atmosphere radiation (TOA), globally averaged surface
M D Palmer, D J McNeall
doaj   +1 more source

"Effects of load, speed and slip angle on wear behaviors of natural rubber composites"

Hecheng xiangjiao gongye, 2023
The effects of load, speed and slip angle on the abrasion and surface temperature of natural rubber composites were investigated using LAT 100 laboratory abrasion tester, and the relationships between energy loss and abrasion, side force and wear surface
HAO Zhen-Yuana, LI Wan-Huaa, WU You-Pinga,b
doaj   +1 more source

Improved analyses of changes and uncertainties in sea surface temperature measured in situ sice the mid-nineteenth century: The HadSST2 dataset [PDF]

, 2006
A new flexible gridded dataset of sea surface temperature (SST) since 1850 is presented and its uncertainties are quantified. This analysis [the Second Hadley Centre Sea Surface Temperature dataset (HadSST2)] is based on data contained within the ...
Folland, C. K., Kennedy, J. J., Brohan, P., Tett, S. F. B., Parker, D. E., Ansell, T. J., Rayner, N. A., Vanicek, M.   +7 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source