Results 111 to 120 of about 4,736,255 (301)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
A short review of modification techniques for titanium dental implant surfaces
Current Directions in Biomedical EngineeringIn the world of dental implants, the essential determinant of success lies in the phenomenon of osseointegration, wherein titanium implants exhibit the ability for robust integration with the surrounding bone and tissue.
Oezcelik Sude, Haeger Andreas
doaj +1 more source
Applied SciencesThe purpose of this study was to investigate the effect of silane treatment of a resin-coated resin-based composite (RBC) base material on its microtensile bond strength (μTBS) to a computer aided-design/computer-aided manufacturing (CAD/CAM) ceramic ...
Akiko Haruyama +2 more
doaj +1 more source
Science and Engineering of Composite Materials, 2018 This experimental study was conducted to investigate the effect of NaOH concentration and treatment time on the flexural properties of Luffa cylindrica fiber-reinforced epoxy composites.
Mohanta Niharika, Acharya Samir K.
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
EFFECT OF SURFACE TREATMENT ON ENAMEL SURFACE ROUGHNESS
Journal of Istanbul University Faculty of Dentistry, 2016 To compare the effects of different methods of surface treatment on enamel roughness.Ninety human maxillary first premolars were randomly divided into three groups (n=30) according to type of enamel surface treatment: I, acid etching; II, Er:YAG laser; III, Nd:YAG laser.
Şeyda Erşahan +1 more
openaire +3 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Loading Surface in the Course of Mechanical- Thermal Treatment and Steady-State Creep of Metals [PDF]
, 2013 : Kinetics of the loading surface of a material gives precious information on the level of the hardening of the material. This paper is concerned with the evolution of the loading surface during successive actions, such as: (i) plastic deformation, (ii)
Ruszinkó, Endre
core
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source