Results 61 to 70 of about 1,467,433 (277)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Multidecadal Changes in the Flow Velocity and Mass Balance of the Hailuogou Glacier in Mount Gongga, Southeastern Tibetan Plateau

Remote Sensing
Maritime glaciers in the southeastern Tibetan Plateau (TP) have experienced important changes in mass and dynamics over the past decades, challenging the regional water supply and glacier-related hazards.
Ju Gu, Yong Zhang, Xiaowei Lyu, Huanhuan Wang, Zongli Jiang, Xin Wang, Junfeng Wei   +6 more
doaj   +1 more source

Free-surface velocity measurements of opaque materials in laser-driven shock-wave experiments using photonic Doppler velocimetry

Matter and Radiation at Extremes, 2021
We present a novel photonic Doppler velocimetry (PDV) design for laser-driven shock-wave experiments. This PDV design is intended to provide the capability of measuring the free-surface velocity of shocked opaque materials in the terapascal range.
N. Nissim, E. Greenberg, M. Werdiger, Y. Horowitz, L. Bakshi, Y. Ferber, B. Glam, A. Fedotov-Gefen, L. Perelmutter, S. Eliezer   +9 more
doaj   +1 more source

Surface-mode microcavity

, 2005
Optical microcavities based on zero-group-velocity surface modes in photonic crystal slabs are studied. It is shown that high quality factors can be easily obtained for such microcavities in photonic crystal slabs.
Joannopoulos J. D., Min Qiu, Sanshui Xiao, Taflove A.   +3 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Critical flow velocity phenomenon in erosion-corrosion of pipelines: determination methods, mechanisms and applications

Journal of Pipeline Science and Engineering, 2021
The critical flow velocity phenomenon is common in erosion-corrosion of many materials. It is of great importance to develop methods to determine the critical flow velocity and understand mechanisms of the phenomenon so that it can be used for proper ...
Z.B. Wang, Y.G. Zheng
doaj   +1 more source

PREDICTING INSTANTANEOUS SUBSURFACE VELOCITY USING SURFACE VELOCITY

Coastal Engineering Proceedings
Instantaneous measurements of water velocity at depth in the nearshore are rich with information about orbital velocities, longshore and cross shore currents, and forces that lead to sediment transport. Yet measurements of detailed subsurface velocities are scarce owing to the difficulties involved in installing and maintaining instruments such as ...
Tyler Mccormack, Julia Hopkins
openaire   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Conventional Point-Velocity Records and Surface Velocity Observations for Estimating High Flow Discharge

Entropy, 2014
Flow velocity measurements using point-velocity meters are normally obtained by sampling one, two or three velocity points per vertical profile. During high floods their use is inhibited due to the difficulty of sampling in lower portions of the flow ...
Giovanni Corato, Abdelhadi Ammari, Tommaso Moramarco   +2 more
doaj   +1 more source