Results 21 to 30 of about 11,710 (214)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

APPROXIMATE DEVELOPMENTS FOR SURFACES OF REVOLUTION [PDF]

Fiabilitate şi Durabilitate, 2016
The purpose of this paper is provide a set of Maple procedures to construct approximate developments of a general surface of revolution generalizing the well-known gore method for ...
Mădălina Roxana Buneci
doaj  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Surfaces of Constant Curvature in the Pseudo-Galilean Space

International Journal of Mathematics and Mathematical Sciences, 2012
We develop the local theory of surfaces immersed in the pseudo-Galilean space, a special type of Cayley-Klein spaces. We define principal, Gaussian, and mean curvatures.
Željka Milin Šipuš, Blaženka Divjak
doaj   +1 more source

Some Properties of Revolution Surfaces in Euclidean 3-space with Conformable Fractional Derivative [PDF]

Assiut University Journal of Multidisciplinary Scientific Research
In this paper, our aim is to study some of the properties of revolution surfaces in Euclidean 3-space that were studied in Ref. [1], using new definition of fractional derivative called conformable fractional derivative, which is a natural extension of ...
Mohamed Soliman, Hamdy Abd-Ellah, Mohamed Basuney   +2 more
doaj   +1 more source

Implementation of computer technologies in descriptive geometry teaching: Surfaces of revolution [PDF]

Facta Universitatis. Series: Architecture and Civil Engineering, 2003
The proper estimation of computer technologies is very important when computers are to be implemented in the educational process. Otherwise, if not implemented properly, the quality of students' education may be seriously imperiled.
Štulić Radovan B., Atanacković Jelena T.   +1 more
doaj   +1 more source

Analytical surfaces for architecture and engineering

Structural Mechanics of Engineering Constructions and Buildings, 2022
Geometers have proposed more than 600 analytical surfaces for implementation. The largest number of these surfaces is used in architecture and mechanical engineering.
Mathieu Gil-Oulbé, Tiékolo Daou, Ousmane Mariko   +2 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source