Results 121 to 130 of about 2,314,466 (304)

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Influence of Surging and Pitching Behaviors on the Power Output and Wake Characteristics of a 15 MW Floating Wind Turbine

Journal of Marine Science and Engineering
This study investigates the impacts of surging and pitching motions on the power generation performance and wake characteristics of an IEA 15 MW offshore wind turbine under specific inflow wind conditions.
Tsung-Yueh Lin, Hoi-Yi Tong, Sai-Kiu Wong, Shiu-Wu Chau   +3 more
doaj   +1 more source

An Open Letter to Netflix

, 2013
If there is one thing that I will be absolutely ashamed in admitting to you, it’s that I love television. Love it. Not in a turn-it-on-watch-whatever-all-TV-rocks kind of way, but in an I’m-overly-obsessed-with-15-shows-at-a-time kind of way, to the ...
Rupert, Elizabeth A.
core  

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Fearless: Anastasia Maisel

, 2014
Working to create a meaningful, respectful, and community-minded Day of Service in honor of Gettysburg College student Emily Silverstein ’11, and continually involved in different farming and food initiatives in the Gettysburg area to promote food ...
Maisel, Anastasia M.
core  

Polymer‐in‐Cage Strategy for Pore Tuning of High‐Aspect Ratio ZIF Nanoplate: Toward Sub‐Micrometer‐Thick Large Area CO2 Separation Membranes

Advanced Science, EarlyView.
A “polymer‐in‐cage” strategy transforms a zinc‐acrylate copolymer into an active pore‐modulating agent for ZIF‐8 nanoplates. The polymer actively tunes the MOF's pore structure by anchoring within its windows, while the nanoplates create tortuous pathways.
Minsu Kim, Hyo Jun Min, Min Kyu Choi, Ki Chul Kim, Bomi Kim, Miso Kang, Nahyeon Lee, Kiwon Eum, Jong Hak Kim, Dae Woo Kim   +9 more
wiley   +1 more source

Fearless: The Vagina Monologues

, 2014
Performed annually around the world to celebrate womanhood, empower survivors of sexual assault and abuse, and create an open forum for challenging cultural attitudes toward women, the Vagina Monologues will be performed by Gettysburg College students ...
Center for Public Service,
core  

Climate Action Impacts on Steelmaking Emissions of Persistent Organic Pollutants Highlight a Gap Between the Paris Agreement and the Stockholm Convention

Advanced Science, EarlyView.
Emissions of unintentionally produced persistent organic pollutants (UPOPs) and global warming are two major environmental challenges. But their governance has largely evolved in parallel, leaving the toxicity implications of climate‐driven industrial transitions poorly understood.
Yuxiang Sun, Qiuting Yang, Jianghui Yun, Yujue Yang, Junhao Tang, Qian Liu, Minghui Zheng, Guorui Liu   +7 more
wiley   +1 more source

Fearless: Ally Siegel

, 2014
Encouraging and mentoring young minds, consistently finding new ways to use her love of climbing and adventure to promote character and leadership development, and always ready for the next big challenge, Ally Siegel ’16 fearlessly pushes herself to ...
Siegel, Alexandra M.
core  

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source