Results 191 to 200 of about 265,562 (294)

Discussion: “Pressure Surges Following Water-Column Separation” (Kephart, J. T., and Davis, Kenneth, 1961, ASME J. Basic Eng., 83, pp. 456–458) [PDF]

, 1961
Rowland Richards
openalex   +3 more sources

Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis

Advanced Science, EarlyView.
Wound infections induce gcFGF8a expression, which subsequently executes direct antimicrobial activity to suppress local infection while simultaneously activating the FGFR4‐mediated ERK/AKT‐mTOR signaling cascade, thereby upregulating HIF1α and enhancing glycolysis. These coordinated actions synergistically promote tissue repair by eliminating pathogens
Ya‐Zhen Hu, Ting Wang, Chang‐Song Wu, Jie Wang, Xue‐Qing Han, Yong‐An Zhang, Xu‐Jie Zhang   +6 more
wiley   +1 more source

Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang, Haoyun Li, Hongfei Wang, Liangyu Shi, Ying Shing Chan, Yu Wang, Graham Ka Hon Shea   +6 more
wiley   +1 more source

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, EarlyView.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

Analysis of Surge

, 1969
John Pickford
openalex   +1 more source

Advanced Temperature Design for Dynamic Performance Enhancement of PEMFCs Under High Current Density (HCD)

Advanced Science, EarlyView.
This study presents an innovative temperature difference (TD) design with an in‐plane gradient to optimize cooling channels in proton exchange membrane fuel cells (PEMFCs) under high current density (HCD) loading. The positive temperature difference (PTD) design improves dynamic response by enhancing hydration upstream and mitigating flooding ...
Fengyang Cai, Shanshan Cai, Zhengkai Tu, Siew Hwa Chan   +3 more
wiley   +1 more source

Ambipolar Charge Transport in Perovskite CsPbBr3 γ‐Ray Detectors with Superior Uniformity and Spectral Resolution by Zone Refining Processing

Advanced Science, EarlyView.
Zone refining processing has been proposed to achieve ultrahigh purity level in perovskite CsPbBr3 crystals, enabling ambipolar charge transport by enhancing the electron transport properties, thereby resulting in better γ‐ray detector performance with exceptional uniformity and reproducibility.
Bao Xiao, Yuquan Wang, Ning Ding, Haoming Qin, Nannan Shen, Xuchang He, Qihao Sun, Yihui He   +7 more
wiley   +1 more source

Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy

Advanced Science, EarlyView.
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao, Xianping Liu, Xu Chu, Feixiang Chen, Ruicheng Shi, Zonghao Liu, Yelin Wu, Yanyan Liu, Wenbo Bu   +8 more
wiley   +1 more source

Effect of Varying Rate Spring with Two Stages on Preventing Surging Phenomenon

, 1969
Masakazu Shibata
openalex   +2 more sources

RSPO2 Coordinates with GDF9:BMP15 Heterodimers to Promote Granulosa Cell and Oocyte Development in Mice

Advanced Science, EarlyView.
RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang, Hongjiang Li, Liji You, Shuhui Wang, Jinglei Bie, Ziyang Su, Lanying Shi, You‐Qiang Su   +7 more
wiley   +1 more source