Results 261 to 270 of about 1,825,580 (317)

Utilizing Caenorhabditis Elegans as a Rapid and Precise Model for Assessing Amphetamine‐Type Stimulants: A Novel Approach to Evaluating New Psychoactive Substances Activity and Mechanisms

open access: yesAdvanced Science, EarlyView.
This study uses Caenorhabditis elegans to assess the activity of amphetamine‐type stimulants (ATS) and their analogs. The research highlights the roles of dopamine and serotonin pathways, distinguishes chiral forms of ATS, and identifies structure‐activity relationships. These findings provide a rapid and cost‐effective model for evaluating the effects
Yuanpeng Li   +3 more
wiley   +1 more source

Bacterial Capture‐Killing Capsules with Remodeling Bone Immune Microenvironment for the Effective Treatment of Osteomyelitis

open access: yesAdvanced Science, EarlyView.
The PC‐O@TOB capsules are designed to exhibit bactericidal effects, regulate the bone immune microenvironment by promoting M2 macrophage polarization, eliminate excessive ROS, and enhance bone regeneration, providing a novel multi‐dimensional approach for the treatment of osteomyelitis.
Dong Yang   +6 more
wiley   +1 more source

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

open access: yesAdvanced Science, EarlyView.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su   +12 more
wiley   +1 more source

TRANSFORMATION OF SURGES

open access: yesTransactions of the Japan Society of Civil Engineers, 1968
Akira Murota, Koichiro Iwata
openaire   +3 more sources

Advanced Temperature Design for Dynamic Performance Enhancement of PEMFCs Under High Current Density (HCD)

open access: yesAdvanced Science, EarlyView.
This study presents an innovative temperature difference (TD) design with an in‐plane gradient to optimize cooling channels in proton exchange membrane fuel cells (PEMFCs) under high current density (HCD) loading. The positive temperature difference (PTD) design improves dynamic response by enhancing hydration upstream and mitigating flooding ...
Fengyang Cai   +3 more
wiley   +1 more source

Ambipolar Charge Transport in Perovskite CsPbBr3 γ‐Ray Detectors with Superior Uniformity and Spectral Resolution by Zone Refining Processing

open access: yesAdvanced Science, EarlyView.
Zone refining processing has been proposed to achieve ultrahigh purity level in perovskite CsPbBr3 crystals, enabling ambipolar charge transport by enhancing the electron transport properties, thereby resulting in better γ‐ray detector performance with exceptional uniformity and reproducibility.
Bao Xiao   +7 more
wiley   +1 more source

Layered Iron Vanadate for High‐Performance and Stable Cathode Material for Aqueous Manganese Batteries

open access: yesAdvanced Science, EarlyView.
An aqueous Mn battery with a high rate and stable cycle performance is demonstrated using layered iron vanadate as the cathode material. The surface‐capacitive contribution governs the reaction mechanism and exceeds the high‐rate performance of the material. Its small interlayer spacing exceeds that of its stable cycle performance.
Seunghyeop Baek   +6 more
wiley   +1 more source

Ultrathin High‐Efficiency Zener Diode Fabricated Using Organized ZnS Nanoparticles in Surface‐Grafted Poly(methacrylic acid) Matrix

open access: yesAdvanced Electronic Materials, EarlyView.
This work presents a unique approach for fabricating homogeneously dispersed ZnS nanoparticles within an ultra‐thin (<40 nm) polymer matrix. The uniformity of dispersion is ensured through post‐polymerization substitution of Zn2⁺‐terminated side groups in surface‐grafted PMAA brushes. Due to the homogeneous distribution of semi‐conducting nanoparticles,
Wojciech Wieczorek   +6 more
wiley   +1 more source

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