Results 311 to 320 of about 2,517,198 (384)

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

open access: yesAdvanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su   +18 more
wiley   +1 more source

The Trigger in IVF Cycles: Molecular Pathways and Clinical Implications. [PDF]

open access: yesInt J Mol Sci
Baldini GM   +7 more
europepmc   +1 more source

A Prussian Blue Nanozyme‐Adjuvanted Vaccine Presenting Phosphocholine Antigens for Induction of Immunotolerance in Inflammatory Bowel Disease

open access: yesAdvanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is a complex disorder characterized by chronic intestinal inflammation and impaired barrier function, for which effective long‐term therapies remain elusive. To address this challenge, we developed a novel nano‐vaccine that combines Prussian blue nanozymes (PBNZs) adjuvants with a ferritin carrier loaded with ...
Jingyi Sheng   +6 more
wiley   +1 more source

Surge of Chikungunya Cases in Central India, Post-COVID-19 Pandemic. [PDF]

open access: yesInfect Dis Clin Microbiol
Sodani S, Taraphdar D, Hawaldar R.
europepmc   +1 more source

Enhanced Photocatalytic CO2 Reduction Performance by External Electric Field‐Driven Charge Separation on Interdigitated Micro‐Spacing Structure

open access: yesAdvanced Science, EarlyView.
An external electric field‐enhanced photocatalytic system is developed using interdigitated electrodes with 100 µm spacing to overcome the liquid‐phase limitations of traditional PEC. The induced high‐intensity electric field effectively drives the directional migration of charge carriers under low voltage. This strategy significantly suppresses charge
Xidan Tang   +7 more
wiley   +1 more source

Pakistan's sudden HIV surge: a national crisis with international implications. [PDF]

open access: yesAnn Med Surg (Lond)
Ali MR   +3 more
europepmc   +1 more source

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