Results 141 to 150 of about 356,601 (260)

Surge arrester leakage current modeling based on pollution layer electrical conductivity estimation. [PDF]

Sci Rep
Hoseini Nejadiyan Kooshki A, Seyyedbarzegar S.   +1 more
europepmc   +1 more source

Transhumanism Without Transindividuation in the Age Without Epochality: Stiegler, Vice, and Radical Human Enhancement

Bioethics, EarlyView.
ABSTRACT At its core, transhumanism is utopic and apocalyptic: it tells us we will be saved through an imminent radical change of our being wrought by radical human enhancement (RHE) technologies. We are rushing, its supporters claim, towards a technological utopia so long as assorted techno‐phobes do not stand in the way.
Benjamin N. Parks
wiley   +1 more source

Human Error Probability Determination in Blasting Process of Ore Mine Using a Hybrid of HEART and Best-Worst Methods. [PDF]

Saf Health Work, 2022
Mirzaei Aliabadi M, Mohammadfam I, Soltanian AR, Najafi K.   +3 more
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Mechanical performance simulation and application of assembled self-centring shear lead damper. [PDF]

Sci Rep
Liu H, Chen Q, Gao Y, Liu S, Liu R, Wen B.   +5 more
europepmc   +1 more source

When Universities Turn Carceral: Between Academic Freedom and Elimination

The British Journal of Sociology, EarlyView.
Gil Rothschild Elyassi
wiley   +1 more source

Chromatin Modifications Orchestrate DNA Repair Pathway Choice: Epigenetics Strategies for Enhancing CRISPR–Cas9‐Mediated Knock‐In Efficiency

Cell Proliferation, EarlyView.
Histone modifications at CRISPR–Cas9‐induced DNA double‐strand breaks shape chromatin states and regulate DNA repair pathway choice. Transient epigenetic modulation may provide a promising strategy to enhance CRISPR–Cas9‐mediated gene knock‐in.
Xin Chen, Shan Qin, Ce Yang, Zhiyao Xing, Chong Liu, Xingchen Zhang, Xi Wu, Xueren Li, Yanhua Gong, Zichuan Liu   +9 more
wiley   +1 more source

Development and practical application of condition monitoring system for ultra-high voltage electrical equipment. [PDF]

Sci Rep
Hu S, Meng M.
europepmc   +1 more source

Iodoacetic Acid, a Water Disinfection Byproduct, Disrupts Hypothalamic, and Pituitary Reproductive Regulatory Factors and Induces Toxicity in the Female Pituitary. [PDF]

Toxicol Sci, 2021
Gonzalez RVL, Weis KE, Gonsioroski AV, Flaws JA, Raetzman LT.   +4 more
europepmc   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source