Results 151 to 160 of about 9,923 (283)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Leakage Current Sensor and Neural Network for  MOA Monitoring. [PDF]

Comput Intell Neurosci, 2022
He T, Li Y, Zhang Z, Shen P, Zhang Y.
europepmc   +1 more source

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

Golden weapons and golden fetters: From the gold standard to the new geopolitics

The Economic History Review, EarlyView.
Abstract This paper explores the historical relationship between monetary regimes, security concerns, and geopolitical tensions, particularly focusing on the role of gold. Throughout history, monetary systems have been deeply intertwined with international state systems and security provisions.
Harold James
wiley   +1 more source

State Integration and Violence at the Margins: The Logic of Police Raids in Rio de Janeiro's Favelas

The Howard Journal of Crime and Justice, EarlyView.
ABSTRACT This paper investigates police raids in Rio de Janeiro's favelas through a property rights framework, exploring their organisational structure, motivations and implications. Using data from police reports, academic studies, NGOs and news sources, it examines why and how the state intervenes in these contested spaces.
Joseph Bouchard
wiley   +1 more source

The Practical Application of Bio-Inspired PMA for the Detection of Partial Discharges in High Voltage Equipment. [PDF]

Sensors (Basel), 2023
Cruz J, Serres A, Freire R, Costa E, Xavier G, Oliveira A, Souza V, Lazaridis P.   +7 more
europepmc   +1 more source

Inflammation‐Regeneration Axis of Dental Pulp Stem Cells: Wnt/NF‐κB Crosstalk

International Endodontic Journal, EarlyView.
ABSTRACT Background Inflammation critically determines dental pulp regenerative outcomes, with dental pulp stem cells (DPSCs) orchestrating tissue homeostasis through differentiation, self‐renewal and immunomodulation processes dynamically regulated by Wnt/β‐catenin and NF‐κB signaling crosstalk.
V. Rajasekar, M. Huang, M. M. Abdalla, P. Neelakantan, C. K. Y. Yiu   +4 more
wiley   +1 more source

A UAV Intelligent System for Greek Power Lines Monitoring. [PDF]

Sensors (Basel), 2023
Tsellou A, Livanos G, Ramnalis D, Polychronos V, Plokamakis G, Zervakis M, Moirogiorgou K.   +6 more
europepmc   +1 more source

Wearable Electronic Monitoring of Vital Signs in Hospitalised Adults: A Nursing Focused Scoping Review of Clinical, Economic and Implementation Outcomes

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To synthesise evidence on wearable devices for continuous vital signs monitoring in adult hospital inpatients, focusing on clinical effectiveness, nursing perspectives, workflow impact, patient experience and resource implications. Design Scoping review.
Sian Myfanwy Shaw, Sophie Bethan Shaw, Gillian Janes   +2 more
wiley   +1 more source

Synergistic Effects of Pr₆O₁₁ and Co₃O₄ on Electrical and Microstructure Features of ZnO-BaTiO₃ Varistor Ceramics. [PDF]

Materials (Basel), 2021
Shaifudin MS, Ghazali MSM, Kamaruzzaman WMIWM, Wan Abdullah WR, Kassim S, Ismail NQA, Sa'at NK, Mohd Zaid MH, Mohd Fekeri MF, Matori KA.   +9 more
europepmc   +1 more source