Results 131 to 140 of about 2,672,563 (309)

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Navigating the challenges of minimally invasive mitral valve surgery: a risk analysis and learning curve evaluation

Journal of Cardiothoracic Surgery
Background This study aimed to report the risk and learning curve analysis of a minimally invasive mitral valve surgery program performed through a right mini-thoracotomy at a single institution.
Nestoras Papadopoulos, Vasileios Ntinopoulos, Stak Dushaj, Achim Häussler, Dragan Odavic, Hector Rodríguez Cetina Biefer, Omer Dzemali   +6 more
doaj   +1 more source

Handbook of emergencies in adult cardiac surgery

, 2015
This book focuses on the essential informations that every student graduating in medicine and surgery and training in cardiac surgery and cardiology should have within reach.
Segreto, A., Congiu, S., Salvatore, S. De, BIZZARRI, Federico, Chiusaroli, A.   +4 more
core  

Outcomes after Perioperative Transient Ischemic Attack Following Cardiac Surgery

Perioperative transient ischemic attacks (PTIAs) are associated with significantly increased rates of postoperative complications such as low cardiac output, atrial fibrillation, and significantly higher mortality in cardiac procedures.
Jeffrey R. Balzer, James Brown, Urvish Jain, Kathirvel Subramaniam, Raul Nogueira, Yisi Wang, Floyd Thoma, Katherine M. Anetakis, Bhav Jain, Ibrahim B. Sultan, Sarah Yousef, Parthasarathy D. Thirumala   +11 more
core   +1 more source

Multiplexed Profiling of Individual Extracellular Vesicles Reveals Lung Cancer‐Associated Protein Signatures

Advanced Science, EarlyView.
Cygnus (Cyclic‐imaging gateway to nanovesicles underlying signature) integrates multiplexed single‐EV protein imaging with a practical analysis workflow to examine EV phenotypes at vesicle, subpopulation, and sample scales. ABSTRACT Lung cancer is frequently diagnosed after curative treatment windows have narrowed, creating a need for minimally ...
Mi Hyeon Cho, Yein Chung, Yoonjeong Choi, Baekdong Cha, Jayeon Song, Nuri Oh, Ala Jo, Thomas S. C. Ng, Hyunho Kim, Hyun‐Kyung Woo, Chang Hyun Kim, Cesar M. Castro, Miles A. Miller, Hakho Lee   +13 more
wiley   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Regionalization of Cardiac Services and the Responsiveness of Treatment Choices [PDF]

Efforts to regionalize cardiac services can increase access costs for patients. This study is the first to quantify this trade off by estimating a demand model for surgery services that is used simulate the effect of centralization of cardiac services on
Justin G. Trogdon
core   +2 more sources

Giant Sinus of Valsalva Aneurysm and Atrial Flutter as a Manifestation of Bicuspid Aortic Valve: A Case Report

Case Reports in Medicine
This article presents a clinical case of successful surgical treatment of a young patient with congenital BAV complicated by the development of a sinus of Valsalva aneurysm (SoVA).
Rustem M. Tuleutayev, Aisulu T. Mussagaliyeva, Aidana Zh Baimagambet, Vildana A. Mineyeva   +3 more
doaj   +1 more source

Effects of remote ischaemic preconditioning on peri-operative myocardial injury and clinical outcomes in patients undergoing elective cardiac bypass surgery [PDF]

, 2015
Ischaemic heart disease (IHD) is a major cause of morbidity and mortality in the world. Coronary artery bypass graft (CABG) surgery is the revascularisation strategy of choice in a significant number of patients, particularly those with diabetes mellitus
Candilio, L
core  

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source