Results 111 to 120 of about 473,637 (290)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Back to the anatomy lab: a forgotten foundation or an ongoing necessity?

BMC Medical Education
Background Anatomy is an essential component of medical education in making accurate diagnoses, performing effective surgical interventions, and ensuring patient safety.
Fulya Temi̇zsoy Korkmaz, Buse Naz Çandir Gürses, Ayşe Nur Balci Yapalak, İlke Ali Gürses   +3 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Modified three-stitch hernioplasty technique

Avicenna Journal of Medicine, 2018
Charalampos Kokkinos, Georgios Anagnostopoulos, Dimitrios Filippou, Panagiotis Skandalakis   +3 more
doaj   +1 more source

Surgical approaches to canine appendicular osteosarcoma part 1- anatomic landmarks and amputation techniques

Frontiers in Veterinary Science
Osteosarcoma (OSA) is the most common primary bone neoplasm affecting dogs and the appendicular bones are frequently affected, accounting for up to 80% of reported cases. After tumor diagnosis and staging, surgery followed by adjuvant chemotherapy is the
Ryshely Sonaly De Moura Borges, Paloma Helena Sanches da Silva, Pedro Antônio Bronhara Pimentel, Renato Dornas de Oliveira Pereira, Angel Almendros, Antonio Giuliano, Rodrigo dos Santos Horta, Paulo Vinícius Tertuliano Marinho   +7 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Surgical outcomes after pneumatic retinopexy, scleral buckle placement, and/or pars plana vitrectomy in cases of primary rhegmatogenous retinal detachment [PDF]

, 2018
PURPOSE: To investigate the outcomes and success rate of surgical intervention for patients diagnosed with primary rhegmatogenous retinal detachment. We investigate the most common and current procedures: pneumatic retinopexy (PR), pars plana vitrectomy ...
Hassad, Ahmed
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Resident perception of Obstetrics and Gynecology(OBGYN) residency pelvic anatomy curriculum: a national study

BMC Medical Education
Background Pelvic Anatomy is an integral part of the educational objectives in Obstetrics and Gynecology (OBGYN) residency. As a surgical subspecialty, mastering pelvic anatomy is imperative in performing successful surgical procedures, reducing surgical
Sharonne Holtzman, Lily McCarthy, Isabel S. Chess, Yara Sifri, Farida Nentin, Frederick Friedman   +5 more
doaj   +1 more source