Results 61 to 70 of about 5,952,480 (297)

Comparative Study of Two Different Intravenous Doses of Tranexamic Acid with Placebo on Surgical Field Quality in Functional Endoscopic Sinus Surgery-A Randomised Clinical Trial [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Intraoperative haemorrhage, which disrupts surgical patency, is a major obstacle for surgeons, especially in endoscopic sinus surgeries. Tranexamic acid is synthetic antifibrinolytic agent that binds competitively at lysine binding site on ...
Tamil Anbu Pannerselvam, Kodali V Rajesh kumar, Ranjith B Karthekeyan   +2 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Scintigraphic assessment of bone status at one year following hip resurfacing : comparison of two surgical approaches using SPECT-CT scan [PDF]

, 2012
Objectives: To study the vascularity and bone metabolism of the femoral head/neck following hip resurfacing arthroplasty, and to use these results to compare the posterior and the trochanteric-flip approaches.
Costa, Matthew L., Williams, N. R., Parsons, Nicholas R., Roberts, P., Achten, Juul, Griffin, Damian R., Amarasekera, Hiran W.   +6 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Clinical review: Goal-directed therapy in high risk surgical patients [PDF]

, 2009
A small group of patients account for the majority of peri-operative morbidity and mortality. These 'high-risk' patients have a poor outcome due to their inability to meet the oxygen transport demands imposed on them by the nature of the surgical ...
Lees, N, Rhodes, A, Hamilton, M
core   +1 more source

Methods of Blood Loss Quantification in Major Abdominal Surgery: A Narrative Review

Acta Medica
Blood loss in major abdominal surgery is an essential parameter in the evaluation of strategies aimed at reducing perioperative bleeding. It is also an important parameter of quality of the surgical procedure, along with postoperative morbidity and ...
Ján Zajak, Jiří Páral, Miroslav Sirový, Šárka Odložilová, Kateřina Vinklerová, Michal Balík, Filip Čečka   +6 more
doaj   +1 more source

Use of tranexamic acid in scoliosis surgery

Хирургия позвоночника, 2016
Objective. To assess the effectiveness of tranexamic acid in the surgical correction of idiopathic scoliosis. Material and Methods. The study included a retrospective analysis of intraoperative and postoperative blood loss during surgical correction ...
Maya N. Lebedeva, Anastasia A. Ivanova, Aleksey V. Palmash, Ivan A. Statsenko, Aleksandr S. Vasyura   +4 more
doaj   +1 more source

Expert surgeons and deep learning models can predict the outcome of surgical hemorrhage from 1 min of video

Scientific Reports, 2022
Major vascular injury resulting in uncontrolled bleeding is a catastrophic and often fatal complication of minimally invasive surgery. At the outset of these events, surgeons do not know how much blood will be lost or whether they will successfully ...
Dhiraj J. Pangal, Guillaume Kugener, Yichao Zhu, Aditya Sinha, Vyom Unadkat, David J. Cote, Ben Strickland, Martin Rutkowski, Andrew Hung, Animashree Anandkumar, X. Y. Han, Vardan Papyan, Bozena Wrobel, Gabriel Zada, Daniel A. Donoho   +14 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source