Results 101 to 110 of about 1,451,625 (299)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Challenges in evaluating surgical innovation [PDF]

, 2009
Research on surgical interventions is associated with several methodological and practical challenges of which few, if any, apply only to surgery. However, surgical evaluation is especially demanding because many of these challenges coincide.
Ergina, Patrick L, Seiler, Christoph M, Boutron, Isabelle, Blazeby, Jane M, Cook, Jonathan Alistair, Clavein, Pierre-Alain, Reeves, Barnaby C   +6 more
core   +2 more sources

CLOSURE #2.5: Kieler e-Journal für Comicforschung [PDF]

, 2016
Auch 2016 reißt das Interesse am Medium Comic nicht ab. Die Zahl der Veröffentlichungen steigt nach wie vor an, wobei kleine Verlage zunehmend den etablierten Häusern das Feld streitig machen.

core   +1 more source

Transcatheter and intraoperative device closure and surgical repair for atrial septal defect

Journal of Cardiothoracic Surgery, 2019
Background Transcatheter and intraoperative device closure for atrial septal defect (ASD) are widely applied to reduce the incision size and the potential for injury during cardiopulmonary bypass (CPB) in conventional surgical repair. No studies had been
Han-Fan Qiu, Qiang Chen, Zhi-Nuan Hong, Liang-Wan Chen, Xue-Shan Huang   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Cyanoacrylate vs. sutures in clean and clean-contaminated surgical wounds – a randomised control study

Innovative Surgical Sciences
Various techniques of closure of surgical incisions have been described ranging from various suture materials, staples and tapes to adhesive compounds. Cyanoacrylate is an adhesive compound available for surgical incision closure.
Aravind Kumkod, Sunil Chapparadallimath G., Chandrasekar Shruthi, Shidlingappa Shirol S., Kamat Vijay, Kulkarni Mukund, Balachandra Sanganal P., Chandran Aswathy, Vaidyanathan Ramesh   +8 more
doaj   +1 more source

Outcomes of post myocardial infarction ventricular septal rupture: Experience from an Indian tertiary cardiac center

Indian Heart Journal
Background: Post myocardial infarction ventricular septal rupture (MI-VSR) is a devastating complication after acute myocardial infarction (AMI); lacks uniform treatment recommendations and carries poor outcomes.
Pramod Sagar, Raghuram Chikkala, Sridhara Suthan, Aayisha Nasser, Kothandam Sivakumar, Rajan Sethuratnam, Valikapthalil Mathew Kurian, Mullasari Sankardas Ajit   +7 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Reto Surgical

Reto Surgical established in the year 1998, is an icon in the field of Surgical Instruments and Dental Instruments manufacturers and suppliers, with decades of rich and professional experience. We are extremely pleased to present this updated Catalogue
reto surgical
core   +5 more sources

Post-surgical Pancreatitis Masquerading as Recurrent Neuroendocrine Cancer [PDF]

, 2010
Neuroendocrine tumours of the pancreas can have a spectrum of behaviour from relatively benign to aggressive. Resection can result in cure although metastatic disease is described.
Oniscu, Anca, Stephen J Wigmore, Adair, Anya, Wigmore, Stephen J, Anya Adair, Anca Oniscu   +5 more
core   +1 more source